Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- eptifibatide
- Refludan (lepirudin)
Interactions between your drugs
lepirudin eptifibatide
Applies to: Refludan (lepirudin), eptifibatide
MONITOR CLOSELY: Concomitant use of thrombin inhibitors and antiplatelet agents may increase the risk of bleeding complications due to additive or synergistic effects on the clotting cascade.
MANAGEMENT: Coadministration of thrombin inhibitors and antiplatelet agents should be undertaken with caution and only after thorough assessment of risks and benefits. Close clinical and laboratory observation for bleeding complications is recommended.
References (3)
- (2001) "Product Information. Refludan (lepirudin)." Hoechst Marion Roussel
- (2001) "Product Information. Acova (argatroban)." SmithKline Beecham
- (2001) "Product Information. Angiomax (bivalirudin)." The Medicines Company
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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