Mekinist and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Mekinist (trametinib).
Trametinib Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may reduce as well as delay the absorption of trametinib. In study subjects, administration of a single dose of trametinib with a high-fat, high-calorie meal decreased peak plasma concentration (Cmax) and systemic exposure (AUC) by 70% and 24%, respectively, and delayed Tmax by approximately 4 hours compared to administration in the fasted state.
MANAGEMENT: Trametinib should be taken at least 1 hour before or 2 hours after a meal.
References
- (2013) "Product Information. Mekinist (trametinib)." GlaxoSmithKline
Mekinist drug interactions
There are 20 drug interactions with Mekinist (trametinib).
Mekinist disease interactions
There are 9 disease interactions with Mekinist (trametinib) which include:
- lung toxicity
- cardiomyopathy
- GI perforation
- hemorrhage
- hepatic impairment
- hyperglycemia
- ocular toxicities
- renal impairment
- venous thromboembolism
More about Mekinist (trametinib)
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- During pregnancy
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- FDA approval history
- Drug class: multikinase inhibitors
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Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.