Topotecan and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with topotecan.
Caffeine Topotecan
Minor Drug Interaction
The cytotoxic and cytostatic activity of topotecan may be diminished in the presence of caffeine. The mechanism is probably formation of complexes between caffeine and topotecan which result in reducing the effective concentration of the free form of topotecan. The clinical implications of this interaction are unknown.
References (1)
- Traganos F, Kapuscinski J, Gong J, Ardelt B, Darzynkiewicz RJ, Darzynkiewicz Z (1993) "Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells." Cancer Res, 53, p. 4613-8
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Topotecan drug interactions
There are 427 drug interactions with topotecan.
Topotecan disease interactions
There are 6 disease interactions with topotecan which include:
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- Drug class: miscellaneous antineoplastics
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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