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Topotecan and Alcohol/Food Interactions

There is 1 alcohol/food/lifestyle interaction with topotecan.

Minor

Caffeine Topotecan

Minor Drug Interaction

The cytotoxic and cytostatic activity of topotecan may be diminished in the presence of caffeine. The mechanism is probably formation of complexes between caffeine and topotecan which result in reducing the effective concentration of the free form of topotecan. The clinical implications of this interaction are unknown.

References (1)
  1. Traganos F, Kapuscinski J, Gong J, Ardelt B, Darzynkiewicz RJ, Darzynkiewicz Z (1993) "Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells." Cancer Res, 53, p. 4613-8

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Topotecan drug interactions

There are 426 drug interactions with topotecan.

Topotecan disease interactions

There are 6 disease interactions with topotecan which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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