Topotecan Disease Interactions
There is 1 disease interaction with topotecan:
Antineoplastics (Includes Topotecan) ↔ Infections
Severe Potential Hazard, High plausibility
Applies to: Infection - Bacterial/Fungal/Protozoal/Viral
Because of their cytotoxic effects on rapidly proliferating tissues, antineoplastic agents frequently can, to varying extent, induce myelosuppression. The use of these drugs may be contraindicated in patients with known infectious diseases. All patients should be instructed to immediately report any signs or symptoms suggesting infection such as fever, sore throat, or local infection during antineoplastic therapy. Close clinical monitoring of hematopoietic function is recommended.
- "Product Information. Novantrone (mitoxantrone)." Immunex Corporation, Seattle, WA.
- "Product Information. Gemzar (gemcitabine)." Lilly, Eli and Company, Indianapolis, IN.
- "Product Information. Taxol (paclitaxel)." Bristol-Myers Squibb, Princeton, NJ.
- "Product Information. Doxil (doxorubicin liposomal)." Sequis Pharmaceuticals Inc, Menlo Park, CA.
- Frame JN, Dahut WL, Crowley S "Fludarabine and acute tumor lysis in chronic lymphocytic leukemia." N Engl J Med 327 (1992): 1396-7
- "Product Information. Fludara (fludarabine)." Berlex, Richmond, CA.
- "Product Information. Leustatin (cladribine)." Ortho Biotech Inc, Raritan, NJ.
- "Product Information. Leukeran Tablets (chlorambucil)." Glaxo Welcome, Research Triangle Pk, NC.
- "Product Information. Matulane (procarbazine)." Roche Laboratories, Nutley, NJ.
- "Product Information. Tabloid (thioguanine)." Glaxo Wellcome, Research Triangle Park, NC.
- "Product Information. Mutamycin (mitomycin)." Bristol-Myers Squibb, Princeton, NJ.
- Sanders C, Perez EA, Lawrence HJ "Opportunistic infections in patients with chronic lymphocytic leukemia following treatment with fludarabine." Am J Hematol 39 (1992): 314-5
- "Product Information. Purinethol (mercaptopurine)." Glaxo Wellcome, Research Triangle Pk, NC.
- "Product Information. Idamycin (idarubicin)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Methotrexate (methotrexate)." Lederle Laboratories, Wayne, NJ.
- "Product Information. Adriamycin PFS (doxorubicin)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Taxotere (docetaxel)." Rhone-Poulenc Rorer, Collegeville, PA.
- "Product Information. Alkeran Tablets (melphalan)." Glaxo Wellcome, Research Triangle Pk, NC.
- "Product Information. Xeloda (capecitabine)." Roche Laboratories, Nutley, NJ.
- Schilling PJ, Vadhan-Raj S "Concurrent cytomegalovirus and pneumocystis pneumonia after fludarabine therapy for chronic lymphocytic leukemia." N Engl J Med 323 (1990): 833-4
- "Product Information. Ifex (ifosfamide)." Bristol-Myers Squibb, Princeton, NJ.
- Bastion Y, Coiffier B, Tigaud JD, Espinouse D, Bryon PA "Pneumocystis pneumonia in a patient treated with fludarabine for chronic lymphocytic leukemia." Eur J Cancer 27 (1991): 671
- "Product Information. Platinol (cisplatin)." Bristol-Myers Squibb, Princeton, NJ.
- "Product Information. Hycamtin (topotecan)." SmithKline Beecham, Philadelphia, PA.
- "Product Information. Cytosar-U (cytarabine)." Pharmacia and Upjohn, Kalamazoo, MI.
- Girmenia C, Mauro FR, Rahimi S "Late listeriosis after fludarabine plus prednisone treatment." Br J Haematol 87 (1994): 407-8
- "Product Information. Vepesid (etoposide)." Bristol-Myers Squibb, Princeton, NJ.
- "Product Information. DTIC-Dome (dacarbazine)." Bayer, West Haven, CT.
- "Product Information. Nipent (pentostatin)." Parke-Davis, Morris Plains, NJ.
- "Product Information. Uracil Mustard (uracil mustard)." Roberts Pharmaceutical Corporation, Eatontown, NJ.
- "Product Information. Thiotepa (thiotepa)." Lederle Laboratories, Wayne, NJ.
topotecan drug Interactions
There are 300 drug interactions with topotecan
topotecan alcohol/food Interactions
There is 1 alcohol/food interaction with topotecan
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.