Sofosbuvir/velpatasvir/voxilaprevir and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with sofosbuvir / velpatasvir / voxilaprevir.
Voxilaprevir Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Administration with food enhances the oral bioavailability of sofosbuvir, velpatasvir, and voxilaprevir. Relative to fasting conditions, mean sofosbuvir systemic exposure (AUC) increased by 64% to 144%, mean velpatasvir AUC increased by 40% to 166%, and mean voxilaprevir AUC increased by 112% to 435% when the combined sofosbuvir/velpatasvir/voxilaprevir formulation is administered with food.
MANAGEMENT: Sofosbuvir/velpatasvir/voxilaprevir should be administered with food.
References (1)
- (2017) "Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir)." Gilead Sciences
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Sofosbuvir/velpatasvir/voxilaprevir drug interactions
There are 237 drug interactions with sofosbuvir / velpatasvir / voxilaprevir.
Sofosbuvir/velpatasvir/voxilaprevir disease interactions
There are 4 disease interactions with sofosbuvir / velpatasvir / voxilaprevir which include:
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- Drug class: antiviral combinations
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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