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Renagel (sevelamer) and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with Renagel (sevelamer) which include:


multivitamins with minerals ↔ sevelamer

Moderate Drug Interaction

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency. In a crossover study involving healthy subjects, coadministration of sevelamer with calcitriol resulted in a significant reduction in bioavailability for calcitriol (calcitriol with sevelamer vs calcitriol alone: AUC 137 pg*h/mL vs 318 pg*h/mL and Cmax 40.1 pg/mL vs 49.7 pg/mL, respectively).

MANAGEMENT: Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.


  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. Peirce D, Hossack S, Poole L, "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21
  3. Cerner Multum, Inc. "Australian Product Information." O 0
  4. "Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.
  5. "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
View all 5 references

sevelamer ↔ food

Moderate Food Interaction

Sevelamer may interact with other medications if taken directly with them. As a precaution, other medications that can be affected by changes in blood levels should be administered 1 hour before or 3 hours after sevelamer. This will make it easier for your body to absorb the medication.

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Renagel (sevelamer) drug Interactions

There are 46 drug interactions with Renagel (sevelamer)

Renagel (sevelamer) disease Interactions

There are 3 disease interactions with Renagel (sevelamer) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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