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Renagel (sevelamer) Disease Interactions

There are 3 disease interactions with Renagel (sevelamer):


Sevelamer (Includes Renagel) ↔ gastrointestinal disease

Severe Potential Hazard, Moderate plausibility. Applies to: Intestinal Obstruction

Sevelamer is contraindicated in patients with bowel obstruction. Cases of bowel obstruction and perforation have been reported with the use of sevelamer. Care and appropriate measures should be taken if patients develop constipation or worsening of existing constipation while on sevelamer.


Sevelamer (Includes Renagel) ↔ dysphagia

Moderate Potential Hazard, Moderate plausibility. Applies to: Dysphagia

Cases of dysphagia and esophageal tablet retention have been reported in association with use of the tablet formulation of sevelamer, some requiring hospitalization and intervention. Consider using sevelamer suspension in patients with a history of swallowing disorders.


Sevelamer (Includes Renagel) ↔ renal disease

Moderate Potential Hazard, Moderate plausibility. Applies to: peritoneal dialysis

Patients on peritoneal dialysis should be closely monitored to ensure the reliable use of appropriate aseptic technique with the prompt recognition and management of any signs and symptoms associated with peritonitis.

Renagel (sevelamer) drug interactions

There are 49 drug interactions with Renagel (sevelamer)

Renagel (sevelamer) alcohol/food interactions

There are 2 alcohol/food interactions with Renagel (sevelamer)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.