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Ponvory and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Ponvory (ponesimod).

Moderate

Ponesimod High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

ponesimod - arrhythmia

The use of ponesimod may result in a transient decrease in heart rate and atrioventricular (AV) conduction delays, especially during treatment initiation. This drug is not recommended in patients with a history of cardiac arrest, cerebrovascular disease (e.g., TIA, stroke occurring more than 6 months prior to treatment initiation), uncontrolled hypertension, or severe untreated sleep apnea, since significant bradycardia may be poorly tolerated in these patients. The use of this drug in patients with a history of recurrent syncope or symptomatic bradycardia should be based on an overall benefit-risk assessment. Obtain an ECG in all patients to determine whether preexisting conduction abnormalities are present and consult a cardiologist if appropriate. Monitor closely patients taking concurrent therapy with drugs that decrease heart rate (e.g., beta-blockers, non-dihydropyridine calcium channel blockers, and other drugs that may decrease heart rate).

References

  1. (2021) "Product Information. Ponvory (ponesimod)." Janssen Pharmaceuticals
Moderate

Ponesimod High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

ponesimod - hypertension

The use of ponesimod may result in increased blood pressure. Care should be exercised when using this drug in hypertensive patients and those at risk for hypertension. It is recommended to monitor blood pressure during treatment and manage it according to clinical practices.

References

  1. (2021) "Product Information. Ponvory (ponesimod)." Janssen Pharmaceuticals

Ponvory drug interactions

There are 653 drug interactions with Ponvory (ponesimod).

Ponvory disease interactions

There are 9 disease interactions with Ponvory (ponesimod) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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