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Interferon alfa-2b / ribavirin and Alcohol / Food Interactions

There is 1 alcohol/food/lifestyle interaction with interferon alfa-2b / ribavirin:

Moderate

ribavirin ↔ food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Food enhances the oral absorption and bioavailability of ribavirin. Administration of a single oral dose of ribavirin following a high-fat meal delayed absorption (Tmax was doubled) but increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by up to 70% compared to administration in the fasting state.

MANAGEMENT: To ensure maximal oral absorption, ribavirin should be administered with or immediately after a meal.

References

  1. "Product Information. Copegus (ribavirin)." Roche Laboratories, Nutley, NJ.
  2. "Product Information. Rebetol (ribavirin)." Schering-Plough Corporation, Kenilworth, NJ.

Interferon alfa-2b / ribavirin drug interactions

There are 251 drug interactions with interferon alfa-2b / ribavirin

Interferon alfa-2b / ribavirin disease interactions

There are 14 disease interactions with interferon alfa-2b / ribavirin which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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