Rebetron (interferon alfa-2b / ribavirin) and Alcohol / Food Interactions
There is 1 alcohol/food/lifestyle interaction with Rebetron (interferon alfa-2b / ribavirin):
ribavirin ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Food enhances the oral absorption and bioavailability of ribavirin. Administration of a single oral dose of ribavirin following a high-fat meal delayed absorption (Tmax was doubled) but increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by up to 70% compared to administration in the fasting state.
MANAGEMENT: To ensure maximal oral absorption, ribavirin should be administered with or immediately after a meal.
References
- "Product Information. Rebetol (ribavirin)." Schering-Plough Corporation, Kenilworth, NJ.
- "Product Information. Copegus (ribavirin)." Roche Laboratories, Nutley, NJ.
Rebetron (interferon alfa-2b / ribavirin) drug Interactions
There are 244 drug interactions with Rebetron (interferon alfa-2b / ribavirin)
Rebetron (interferon alfa-2b / ribavirin) disease Interactions
There are 14 disease interactions with Rebetron (interferon alfa-2b / ribavirin) which include:
- Renal Dysfunction
- Autoimmune Diseases
- Hepatic Dysfunction
- Cardiac Disease
- Cns Dysfunction
- Depression
- Thyroid Dysfunction
- Anemia
- Pulmonary Deterioration
- Renal Dysfunction
- Colitis
- Diabetes Mellitus
- Myelosuppression
- Peripheral Neuropathy
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No information available. |
Do not stop taking any medications without consulting your healthcare provider.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
