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Rebetron (interferon alfa-2b / ribavirin) and Alcohol / Food Interactions

There is 1 alcohol/food/lifestyle interaction with Rebetron (interferon alfa-2b / ribavirin):

Moderate

ribavirin ↔ food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Food enhances the oral absorption and bioavailability of ribavirin. Administration of a single oral dose of ribavirin following a high-fat meal delayed absorption (Tmax was doubled) but increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by up to 70% compared to administration in the fasting state.

MANAGEMENT: To ensure maximal oral absorption, ribavirin should be administered with or immediately after a meal.

References

  1. "Product Information. Copegus (ribavirin)." Roche Laboratories, Nutley, NJ.
  2. "Product Information. Rebetol (ribavirin)." Schering-Plough Corporation, Kenilworth, NJ.

Rebetron (interferon alfa-2b / ribavirin) drug Interactions

There are 247 drug interactions with Rebetron (interferon alfa-2b / ribavirin)

Rebetron (interferon alfa-2b / ribavirin) disease Interactions

There are 14 disease interactions with Rebetron (interferon alfa-2b / ribavirin) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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