Donatussin DC (guaifenesin / hydrocodone / phenylephrine) and Alcohol / Food Interactions
There is 1 alcohol/food/lifestyle interaction with Donatussin DC (guaifenesin / hydrocodone / phenylephrine):
HYDROcodone ↔ food
Major Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may potentiate the central nervous system (CNS) depressant effects of opioid analgesics including hydrocodone. Concomitant use may result in additive CNS depression and impairment of judgment, thinking, and psychomotor skills. In more severe cases, hypotension, respiratory depression, profound sedation, coma, or even death may occur.
GENERALLY AVOID: Consumption of alcohol while taking some sustained-release formulations of hydrocodone may cause rapid release of the drug, resulting in high systemic levels of hydrocodone that may be potentially lethal. Alcohol apparently can disrupt the release mechanism of some sustained-release formulations. In study subjects, the rate of absorption of hydrocodone from an extended-release formulation was found to be affected by coadministration with 40% alcohol in the fasted state, as demonstrated by an average 2.4-fold (up to 3.9-fold in one subject) increase in hydrocodone peak plasma concentration and a decrease in the time to peak concentration. Alcohol also increased the extent of absorption by an average of 1.2-fold (up to 1.7-fold in one subject).
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of hydrocodone. The proposed mechanism is inhibition of CYP450 3A4-mediated metabolism of hydrocodone by certain compounds present in grapefruit. Increased hydrocodone concentrations could conceivably increase or prolong adverse drug effects and may cause potentially fatal respiratory depression.
MANAGEMENT: Patients taking sustained-release formulations of hydrocodone should not consume alcohol or use medications that contain alcohol. In general, potent narcotics such as hydrocodone should not be combined with alcohol. Patients should also avoid consumption of grapefruit or grapefruit juice during treatment with hydrocodone.
- "Product Information. Zohydro ER (HYDROcodone)." Zogenix, Inc, San Diego, CA.
Donatussin DC (guaifenesin / hydrocodone / phenylephrine) drug Interactions
There are 972 drug interactions with Donatussin DC (guaifenesin / hydrocodone / phenylephrine)
Donatussin DC (guaifenesin / hydrocodone / phenylephrine) disease Interactions
There are 20 disease interactions with Donatussin DC (guaifenesin / hydrocodone / phenylephrine) which include:
- Impaired Gi Motility
- Infectious Diarrhea
- Liver Disease
- Renal Dysfunction
- Acute Alcohol Intoxication
- Drug Dependence
- Intracranial Pressure
- Respiratory Depression
- Cardiovascular Disease
- Adrenal Insufficiency
- Biliary Spasm
- Seizure Disorders
- Urinary Retention
Drug Interaction Classification
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.