Baraclude and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Baraclude (entecavir).
Entecavir Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food delays the oral absorption and reduces the oral bioavailability of entecavir. According to the product labeling, administration of entecavir 0.5 mg with a standard high-fat meal or a light meal resulted in a delay in absorption by 0.25 to 0.75 hours, a decrease in the peak plasma concentration (Cmax) by 44% to 46%, and a decrease in the area under the plasma concentration-time curve (AUC) by 18% to 20% compared to administration in the fasting state.
MANAGEMENT: To ensure maximal oral absorption, entecavir should be administered on an empty stomach at least 2 hours after a meal and 2 hours before the next meal.
References (1)
- (2005) "Product Information. Baraclude (entecavir)." Bristol-Myers Squibb
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Baraclude drug interactions
There are 159 drug interactions with Baraclude (entecavir).
Baraclude disease interactions
There are 3 disease interactions with Baraclude (entecavir) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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