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Dexamethasone / moxifloxacin and Alcohol/Food Interactions

There are 4 alcohol/food/lifestyle interactions with dexamethasone / moxifloxacin which include:

Major

dexamethasone multivitamins with minerals

Major Drug Interaction

Moxifloxacin and other medications in its class can cause tendinitis and tendon rupture, and the risk may be increased when combined with a steroid such as dexamethasone. Older adults over 60 years of age and those who have received a kidney, heart, and/or lung transplant may be particularly susceptible. Tendon rupture can occur during or up to several months after finishing moxifloxacin treatment and may require surgery or result in prolonged disability. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Stop taking moxifloxacin and call your doctor immediately if you experience pain, swelling, or inflammation of a tendon area such as the back of the ankle, shoulder, biceps, hand, or thumb. You should also avoid exercise or use of the affected area until further instruction from your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

multivitamins with minerals moxifloxacin

Moderate Drug Interaction

Moxifloxacin and multivitamin with minerals should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of moxifloxacin into the bloodstream and reduce its effectiveness. If possible, it may be best to avoid taking multivitamin with minerals while you are being treated with moxifloxacin. Otherwise, moxifloxacin should be taken 2 to 4 hours before or 4 to 6 hours after a multivitamin with minerals dose, moxifloxacin should be taken at least 2 hours before and not less than 6 hours after Suprep Bowel Prep (magnesium/potassium/sodium sulfates), or moxifloxacin and multivitamin with minerals should be taken as directed by your healthcare provider. Talk to your healthcare provider if you are unsure whether your medications contain something that could potentially interact or if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

corticosteroids - fluid retention

Corticosteroids may cause hypernatremia, hypokalemia, fluid retention, and elevation in blood pressure. These mineralocorticoid effects are most significant with fludrocortisone, followed by hydrocortisone and cortisone, then by prednisone and prednisolone. The remaining corticosteroids, betamethasone, dexamethasone, methylprednisolone, and triamcinolone, have little mineralocorticoid activities. However, large doses of any corticosteroid can demonstrate these effects, particularly if given for longer than brief periods. Therapy with corticosteroids should be administered cautiously in patients with preexisting fluid retention, hypertension, congestive heart failure, and/or renal dysfunction. Dietary sodium restriction and potassium supplementation may be advisable.

References

  1. Klepikov PV, Kutyrina IM, Tareyeva IE "Steroid-induced hypertension in patients with nephrotic syndrome." Nephron 48 (1988): 286-90
  2. Pang S, Clark AT, Freeman LC, Dolan LM, Immken L, Mueller OT, Stiff D, Shulman DI "Maternal side effects of prenatal dexamethasone therapy for fetal congenital adrenal hyperplasia." J Clin Endocrinol Metab 75 (1992): 249-53
  3. Jackson SH, Beevers DG, Myers K "Does long-term low-dose corticosteroid therapy cause hypertension?" Clin Sci 61 (1981): s381-3
  4. "Product Information. Hydeltrasol (prednisolone)." Merck & Co, Inc, West Point, PA.
  5. Swartz SL, Dluhy RG "Corticosteroids: clinical pharmacology and therapeutic use." Drugs 16 (1978): 238-55
  6. "Product Information. Hydrocortone (hydrocortisone)." Merck & Co, Inc, West Point, PA.
  7. "Product Information. Cortone Acetate (cortisone)." Merck & Co, Inc, West Point, PA.
  8. Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42
  9. "Product Information. Decadron (dexamethasone)." Merck & Co, Inc, West Point, PA.
  10. "Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn, Kalamazoo, MI.
  11. "Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb, Princeton, NJ.
  12. "Product Information. Deltasone (prednisone)." Pharmacia and Upjohn, Kalamazoo, MI.
  13. "Product Information. Celestone (betamethasone)." Schering Corporation, Kenilworth, NJ.
  14. Lieberman P, Patterson R, Kunske R "Complications of long-term steroid therapy for asthma." J Allergy Clin Immunol 49 (1972): 329-36
  15. Ramsahoye BH, Davies SV, el-Gaylani N, Sandeman D, Scanlon MF "The mineralocorticoid effects of high dose hydrocortisone." BMJ 310 (1995): 656-7
  16. "Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb, Princeton, NJ.
  17. Baethge BA, Lidsky MD, Goldberg JW "A study of adverse effects of high-dose intravenous (pulse) methylprednisolone therapy in patients with rheumatic disease." Ann Pharmacother 26 (1992): 316-20
  18. Thomas TP "The complications of systemic corticosteroid therapy in the elderly." Gerontology 30 (1984): 60-5
View all 18 references
Moderate

High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Moderate Potential Hazard, Moderate plausibility

corticosteroids - hyperlipidemia

Corticosteroids may elevate serum triglyceride and LDL cholesterol levels if used for longer than brief periods. Patients with preexisting hyperlipidemia may require closer monitoring during prolonged corticosteroid therapy, and adjustments made accordingly in their lipid-lowering regimen.

References

  1. "Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb, Princeton, NJ.
  2. "Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb, Princeton, NJ.
  3. "Product Information. Decadron (dexamethasone)." Merck & Co, Inc, West Point, PA.
  4. "Product Information. Cortone Acetate (cortisone)." Merck & Co, Inc, West Point, PA.
  5. Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42
  6. "Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn, Kalamazoo, MI.
  7. "Product Information. Hydeltrasol (prednisolone)." Merck & Co, Inc, West Point, PA.
  8. "Product Information. Hydrocortone (hydrocortisone)." Merck & Co, Inc, West Point, PA.
  9. "Product Information. Deltasone (prednisone)." Pharmacia and Upjohn, Kalamazoo, MI.
  10. "Product Information. Celestone (betamethasone)." Schering Corporation, Kenilworth, NJ.
View all 10 references

Dexamethasone / moxifloxacin drug interactions

There are 907 drug interactions with dexamethasone / moxifloxacin

Dexamethasone / moxifloxacin disease interactions

There are 33 disease interactions with dexamethasone / moxifloxacin which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.