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Darbepoetin alfa and Alcohol / Food Interactions

There is 1 alcohol/food/lifestyle interaction with darbepoetin alfa:


High Blood Pressure (Hypertension)

Severe Potential Hazard, Moderate plausibility

erythropoiesis-stimulating agents - hypertension

The use of erythropoiesis-stimulating agents is contraindicated in patients with uncontrolled hypertension. Epoetin alfa and darbepoetin alfa may cause blood pressure to rise. Hypertensive encephalopathy and seizures have been observed in patients with chronic renal failure treated with these agents. Blood pressure should be adequately controlled prior to initiation of therapy, and monitored closely during treatment. Aggressive antihypertensive measures may be necessary, particularly early on in treatment when the hematocrit is increasing. It is recommended to reduce or withhold the use of these agents if blood pressure becomes difficult to control.


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  2. Raine AE "Hypertension, blood viscosity, and cardiovascular morbidity in renal failure: implications of erythropoietin therapy." Lancet 1 (1988): 97-100
  3. Buckner FS, Eschbach JW, Haley NR, Davidson RC, Adamson JW "Hypertension following erythropoietin therapy in anemic hemodialysis patients." Am J Hypertens 3 (1990): 947-55
  4. "Product Information. Procrit (epoetin alfa)." Ortho Biotech Inc, Raritan, NJ.
  5. Bennett WM "Side effects of erythropoietin therapy." Am J Kidney Dis 18 (1991): 84-6
  6. "Product Information. Epogen (epoetin alfa)." Amgen, Thousand Oaks, CA.
  7. Singbartl G "Adverse events of erythropoietin in long-term and in acute short-term treatment." Clin Investig 72 (1994): s36-43
View all 7 references

darbepoetin alfa drug Interactions

There are 30 drug interactions with darbepoetin alfa

darbepoetin alfa disease Interactions

There are 4 disease interactions with darbepoetin alfa which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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