Cobicistat / elvitegravir / emtricitabine / tenofovir alafenamide and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with cobicistat / elvitegravir / emtricitabine / tenofovir alafenamide which include:
elvitegravir ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Food enhances the oral bioavailabilities of both elvitegravir and tenofovir. When a single dose of cobicistat/elvitegravir/emtricitabine/tenofovir (trade name Stribild) was given with a light meal (approximately 373 kcal; 20% fat), mean elvitegravir and tenofovir systemic exposures (AUCs) increased by 34% and 24%, respectively, relative to fasting conditions. When administered with a high-fat meal (approximately 800 kcal; 50% fat), the mean AUC of elvitegravir and tenofovir increased by 87% and 23%, respectively, relative to fasting conditions. The alterations in mean AUCs of cobicistat and emtricitabine were not clinically significant with either the light or high-fat meal.
MANAGEMENT: Cobicistat/elvitegravir/emtricitabine/tenofovir as a fixed-dose preparation should be administered once daily with food. Elvitegravir as a single-ingredient preparation should also be administered once daily with food.
- "Product Information. Vitekta (elvitegravir)." Gilead Sciences, Foster City, CA.
- "Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov)." Gilead Sciences, Foster City, CA.
tenofovir ↔ food
Minor Food Interaction
Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
For clinical details see professional interaction data.
cobicistat / elvitegravir / emtricitabine / tenofovir alafenamide drug Interactions
There are 876 drug interactions with cobicistat / elvitegravir / emtricitabine / tenofovir alafenamide
cobicistat / elvitegravir / emtricitabine / tenofovir alafenamide disease Interactions
There are 7 disease interactions with cobicistat / elvitegravir / emtricitabine / tenofovir alafenamide which include:
- Renal Dysfunction
- Creatinine Clearance
- Renal Dysfunction
- Bone Toxicity
- Liver Disease
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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