Pletal and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Pletal (cilostazol).
Cilostazol Food
Moderate Food Interaction
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of cilostazol. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.
MANAGEMENT: Until more information is available, the manufacturer recommends avoiding consumption of grapefruit juice during cilostazol therapy. Orange juice is not expected to interact with cilostazol.
References (1)
- (2001) "Product Information. Pletal (cilostazol)." Otsuka American Pharmaceuticals Inc
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Pletal drug interactions
There are 468 drug interactions with Pletal (cilostazol).
Pletal disease interactions
There are 4 disease interactions with Pletal (cilostazol) which include:
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More about Pletal (cilostazol)
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- During pregnancy
- Drug class: miscellaneous cardiovascular agents
- Breastfeeding
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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