Pletal (cilostazol) Disease Interactions
There are 4 disease interactions with Pletal (cilostazol):
Cilostazol (applies to Pletal) bleeding
Major Potential Hazard, Moderate plausibility. Applicable conditions: Coagulation Defect
Cilostazol inhibits platelet aggregation in a reversible manner. Cilostazol has not been studied in patients with hemostatic disorders or active pathologic bleeding. Avoid use of cilostazol tablets in these patients.
Cilostazol (applies to Pletal) heart failure
Major Potential Hazard, Moderate plausibility. Applicable conditions: Congestive Heart Failure
The use of cilostazol is contraindicated in patients with heart failure of any severity. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III- IV heart failure.
Cilostazol (applies to Pletal) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
No cilostazol dose adjustment is required in patients with mild hepatic impairment. Patients with moderate or severe hepatic impairment have not been studied in clinical trials and dosing recommendations cannot be provided. Caution is advised if used in these patients.
Cilostazol (applies to Pletal) ischemic heart disease
Moderate Potential Hazard, Moderate plausibility.
Cilostazol may induce tachycardia, palpitation, tachyarrhythmia or hypotension. The increase in heart rate associated with cilostazol is approximately 5 to 7 bpm. Patients with a history of ischemic heart disease may be at risk for exacerbations of angina pectoris or myocardial infarction. Caution is advised.
Pletal (cilostazol) drug interactions
There are 422 drug interactions with Pletal (cilostazol)
Pletal (cilostazol) alcohol/food interactions
There is 1 alcohol/food interaction with Pletal (cilostazol)
More about Pletal (cilostazol)
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- Drug class: miscellaneous cardiovascular agents
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|