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Pletal Disease Interactions

There are 4 disease interactions with Pletal (cilostazol).

Major

Cilostazol (applies to Pletal) bleeding

Major Potential Hazard, Moderate plausibility. Applicable conditions: Coagulation Defect

Cilostazol inhibits platelet aggregation in a reversible manner. Cilostazol has not been studied in patients with hemostatic disorders or active pathologic bleeding. Avoid use of cilostazol tablets in these patients.

Major

Cilostazol (applies to Pletal) heart failure

Major Potential Hazard, Moderate plausibility. Applicable conditions: Congestive Heart Failure

The use of cilostazol is contraindicated in patients with heart failure of any severity. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III- IV heart failure.

Moderate

Cilostazol (applies to Pletal) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

No cilostazol dose adjustment is required in patients with mild hepatic impairment. Patients with moderate or severe hepatic impairment have not been studied in clinical trials and dosing recommendations cannot be provided. Caution is advised if used in these patients.

Moderate

Cilostazol (applies to Pletal) ischemic heart disease

Moderate Potential Hazard, Moderate plausibility.

Cilostazol may induce tachycardia, palpitation, tachyarrhythmia or hypotension. The increase in heart rate associated with cilostazol is approximately 5 to 7 bpm. Patients with a history of ischemic heart disease may be at risk for exacerbations of angina pectoris or myocardial infarction. Caution is advised.

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Pletal drug interactions

There are 465 drug interactions with Pletal (cilostazol).

Pletal alcohol/food interactions

There is 1 alcohol/food interaction with Pletal (cilostazol).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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