Bosulif and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Bosulif (bosutinib).
Bosutinib Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of bosutinib. When given with a high-fat meal, bosutinib peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 1.8- and 1.7-fold, respectively.
GENERALLY AVOID: Coadministration with grapefruit juice is likely to increase the plasma concentrations of bosutinib, which is primarily metabolized by CYP450 3A4. However, the interaction has not been studied. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
MANAGEMENT: Bosutinib should be administered with a meal. The consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit extract should be avoided.
References (1)
- (2012) "Product Information. Bosulif (bosutinib)." Pfizer U.S. Pharmaceuticals Group
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Bosulif drug interactions
There are 571 drug interactions with Bosulif (bosutinib).
Bosulif disease interactions
There are 6 disease interactions with Bosulif (bosutinib) which include:
- cardiovascular disease
- fluid retention
- bone marrow suppression
- dehydration
- liver disease
- renal impairment
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- Drug class: BCR-ABL tyrosine kinase inhibitors
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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