Boceprevir and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with boceprevir.
Boceprevir Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food significantly enhances the oral bioavailability of boceprevir. When given at 800 mg three times daily with food, boceprevir exposure increased by up to 65% relative to administration in the fasting state. The bioavailability of boceprevir was similar regardless of meal type (e.g., high-fat versus low-fat) or whether taken 5 minutes prior to eating, during a meal, or immediately following completion of the meal. Therefore, boceprevir may be taken without regard to either meal type or timing of the meal.
MANAGEMENT: To ensure maximal oral absorption, boceprevir should be administered with a meal or light snack.
References (1)
- (2011) "Product Information. Victrelis (boceprevir)." Schering-Plough Corporation
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Boceprevir drug interactions
There are 472 drug interactions with boceprevir.
Boceprevir disease interactions
There is 1 disease interaction with boceprevir which include:
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- During pregnancy
- Drug class: protease inhibitors
- Breastfeeding
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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