FIRST Mouthwash BLM (aluminum hydroxide / diphenhydramine / lidocaine / magnesium hydroxide / simethicone topical) and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with FIRST Mouthwash BLM (aluminum hydroxide / diphenhydramine / lidocaine / magnesium hydroxide / simethicone topical) which include:
diphenhydrAMINE ↔ Alcohol (Ethanol)
Moderate Drug Interaction
Ask your doctor before using diphenhydrAMINE together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking diphenhydrAMINE. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
aluminum hydroxide ↔ food
Major Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: The concomitant administration of aluminum-containing products (e.g., antacids and phosphate binders) and citrates may significantly increase serum aluminum concentrations, resulting in toxicity. Citrates or citric acid are contained in numerous soft drinks, citrus fruits, juices, and effervescent and dispersible drug formulations. Citrates enhance the gastrointestinal absorption of aluminum by an unknown mechanism, which may involve the formation of a soluble aluminum-citrate complex. Various studies have reported that citrate increases aluminum absorption by 4.6- to 50-fold in healthy subjects. Patients with renal insufficiency are particularly at risk of developing hyperaluminemia and encephalopathy. Fatalities have been reported. Patients with renal failure or on hemodialysis may also be at risk from soft drinks and effervescent and dispersible drug formulations that contain citrates or citric acid. It is unknown what effect citrus fruits or juices would have on aluminum absorption in healthy patients.
MANAGEMENT: The concomitant use of aluminum- and citrate-containing products and foods should be avoided by renally impaired patients. Hemodialysis patients should especially be cautioned about effervescent and dispersible over-the-counter remedies and soft drinks. Some experts also recommend that healthy patients should separate doses of aluminum-containing antacids and citrates by 2 to 3 hours.
ADJUST DOSING INTERVAL: The administration of aluminum-containing antacids with enteral nutrition may result in precipitation, formation of bezoars, and obstruction of feeding tubes. The proposed mechanism is the formation of an insoluble complex between the aluminum and the protein in the enteral feeding. Several cases of esophageal plugs and nasogastric tube obstructions have been reported in patients receiving high-protein liquids and an aluminum hydroxide-magnesium hydroxide antacid or an aluminum hydroxide antacid.
MANAGEMENT: Some experts recommend that antacids should not be mixed with or given after high protein formulations, that the antacid dose should be separated from the feeding by as much as possible, and that the tube should be thoroughly flushed before administration.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67
FIRST Mouthwash BLM (aluminum hydroxide / diphenhydramine / lidocaine / magnesium hydroxide / simethicone topical) drug Interactions
There are 1123 drug interactions with FIRST Mouthwash BLM (aluminum hydroxide / diphenhydramine / lidocaine / magnesium hydroxide / simethicone topical)
FIRST Mouthwash BLM (aluminum hydroxide / diphenhydramine / lidocaine / magnesium hydroxide / simethicone topical) disease Interactions
There are 9 disease interactions with FIRST Mouthwash BLM (aluminum hydroxide / diphenhydramine / lidocaine / magnesium hydroxide / simethicone topical) which include:
- Anticholinergic Effects
- Renal Dysfunction
- Renal/Liver Disease
- Liver Disease
- Resp Depression
Drug Interaction Classification
Do not stop taking any medications without consulting your healthcare provider.