Lorlatinib Drug Interactions
A total of 457 drugs are known to interact with lorlatinib.
- 94 major drug interactions
- 354 moderate drug interactions
- 9 minor drug interactions
Check for interactions
Most frequently checked interactions
View interaction reports for lorlatinib and the medicines listed below.
- Aridol (mannitol)
- Brevital Sodium (methohexital)
- Cerebyx (fosphenytoin)
- Clobex (clobetasol topical)
- CoQ10 (ubiquinone)
- Decadron with Xylocaine (dexamethasone / lidocaine)
- DHEA (dehydroepiandrosterone)
- Dilantin (phenytoin)
- Fentanyl Transdermal System (fentanyl)
- GastroMARK (ferumoxsil)
- Geref Diagnostic (sermorelin)
- Lovaza (omega-3 polyunsaturated fatty acids)
- Lyrica (pregabalin)
- Mesantoin (mephenytoin)
- Methergine (methylergonovine)
- Nembutal (pentobarbital)
- Paracetamol (acetaminophen)
- Peganone (ethotoin)
- Skyrizi (risankizumab)
- Vitamin D3 (cholecalciferol)
Lorlatinib alcohol/food interactions
There are 2 alcohol/food interactions with lorlatinib
Lorlatinib disease interactions
There are 5 disease interactions with lorlatinib which include:
- atrioventricular block
- CNS effects
- hepatotoxicity/hepatic impairment
- hyperlipidemia
- severe renal impairment
More about lorlatinib
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- En Español
- Drug class: multikinase inhibitors
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.