Lorlatinib Drug Interactions
Currently displaying a list of 541 drugs known to interact with lorlatinib.
- 143 major drug interactions
- 384 moderate drug interactions
- 14 minor drug interactions
Medications known to interact with lorlatinib
Note: Showing generic names only.
A
- abametapir topical
- abemaciclib
- abiraterone
- abrocitinib
- acalabrutinib
- acetaminophen
- acetohexamide
- acoramidis
- afatinib
- albendazole
- alfentanil
- alfuzosin
- aliskiren
- almotriptan
- alosetron
- alpelisib
- alprazolam
- ambrisentan
- amiodarone
- amitriptyline
- amlodipine
- amprenavir
- apalutamide
- apixaban
- apremilast
- aprepitant
- aprocitentan
- aripiprazole
- armodafinil
- artesunate
- asenapine
- astemizole
- atazanavir
- atezolizumab
- atogepant
- atorvastatin
- atrasentan
- avacopan
- avanafil
- avapritinib
- avelumab
- axitinib
B
- bedaquiline
- belumosudil
- belzutifan
- benzgalantamine
- berotralstat
- betamethasone
- betrixaban
- bexarotene
- bicalutamide
- boceprevir
- bortezomib
- bosentan
- bosutinib
- brentuximab
- brexpiprazole
- brigatinib
- bromocriptine
- budesonide
- buprenorphine
- bupropion
- buspirone
- butorphanol
C
- cabazitaxel
- cabozantinib
- candesartan
- capivasertib
- capmatinib
- carbamazepine
- cariprazine
- carvedilol
- caspofungin
- celecoxib
- cemiplimab
- cenobamate
- ceritinib
- cerivastatin
- cevimeline
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chlorotrianisene
- chlorpropamide
- cilostazol
- cimetidine
- cinacalcet
- ciprofloxacin
- cisapride
- citalopram
- cladribine
- clarithromycin
- clonazepam
- clorazepate
- clotrimazole
- cobicistat
- cobimetinib
- codeine
- colchicine
- conivaptan
- conjugated estrogens
- conjugated estrogens topical
- copanlisib
- cosibelimab
- crinecerfont
- crizotinib
- cyclobenzaprine
- cyclophosphamide
- cyclosporine
D
- dabigatran
- dabrafenib
- daclatasvir
- danazol
- dapagliflozin
- dapsone
- dapsone topical
- daridorexant
- darifenacin
- darolutamide
- darunavir
- dasatinib
- deferasirox
- deferiprone
- deflazacort
- dehydroepiandrosterone
- delavirdine
- deucravacitinib
- dexamethasone
- diazepam
- diclofenac
- dienestrol topical
- diflunisal
- digoxin
- dihydroergotamine
- diltiazem
- disopyramide
- docetaxel
- dofetilide
- dolasetron
- dolutegravir
- donepezil
- doravirine
- dostarlimab
- doxepin
- doxercalciferol
- doxorubicin
- doxorubicin liposomal
- dronabinol
- dronedarone
- drospirenone
- durvalumab
- dutasteride
- duvelisib
E
- edoxaban
- efavirenz
- elacestrant
- elagolix
- eletriptan
- eliglustat
- eltrombopag
- elvitegravir
- empagliflozin
- encorafenib
- enfortumab vedotin
- entrectinib
- enzalutamide
- eplerenone
- erdafitinib
- ergonovine
- ergotamine
- erlotinib
- erythromycin
- escitalopram
- eslicarbazepine
- estazolam
- esterified estrogens
- estradiol
- estradiol topical
- estrone
- estropipate
- estropipate topical
- eszopiclone
- ethinyl estradiol
- ethosuximide
- etonogestrel
- etoposide
- etrasimod
- etravirine
- everolimus
- exemestane
F
- fedratinib
- felodipine
- fenfluramine
- fentanyl
- fesoterodine
- fexinidazole
- fexofenadine
- finerenone
- fingolimod
- flibanserin
- fluconazole
- fludrocortisone
- fluoxetine
- flurazepam
- flurbiprofen
- fluticasone
- fluvastatin
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosphenytoin
- fostamatinib
- fostemsavir
- fruquintinib
- futibatinib
G
- galantamine
- ganaxolone
- gefitinib
- gemfibrozil
- gepirone
- gilteritinib
- glasdegib
- glimepiride
- glipizide
- glyburide
- goldenseal
- granisetron
- grepafloxacin
- guanfacine
H
I
- ibrexafungerp
- ibrutinib
- ibuprofen
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- indinavir
- indomethacin
- infigratinib
- ipilimumab
- irbesartan
- irinotecan
- irinotecan liposomal
- isavuconazonium
- isoniazid
- isotretinoin
- isradipine
- istradefylline
- itraconazole
- ivabradine
- ivacaftor
- ivermectin
- ixabepilone
- ixazomib
K
L
- lacosamide
- lanreotide
- lapatinib
- larotrectinib
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- leniolisib
- lesinurad
- letermovir
- letrozole
- levamlodipine
- levobupivacaine
- levoketoconazole
- levomethadyl acetate
- levonorgestrel
- lidocaine
- linagliptin
- lomitapide
- lonafarnib
- lonapegsomatropin
- loratadine
- lorazepam
- losartan
- lovastatin
- lumateperone
- lurasidone
- lurbinectedin
M
- macimorelin
- macitentan
- maraviroc
- maribavir
- mavacamten
- mavorixafor
- medroxyprogesterone
- mefenamic acid
- mefloquine
- megestrol
- meloxicam
- meperidine
- mephenytoin
- methadone
- methylergonovine
- methylprednisolone
- methysergide maleate
- mibefradil
- miconazole
- midazolam
- midostaurin
- mifepristone
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- montelukast
- morphine
- mycophenolic acid
N
- nafcillin
- naldemedine
- naloxegol
- naproxen
- nateglinide
- nefazodone
- nelfinavir
- neratinib
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nintedanib
- niraparib
- nirogacestat
- nisoldipine
- nitisinone
- nivolumab
- norethindrone
- norgestrel
O
- octreotide
- olaparib
- oliceridine
- olutasidenib
- omaveloxolone
- ondansetron
- oritavancin
- osilodrostat
- osimertinib
- oxazepam
- oxybutynin
- oxycodone
- ozanimod
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- palovarotene
- panobinostat
- pantoprazole
- paricalcitol
- pasireotide
- pazopanib
- pembrolizumab
- pemigatinib
- penpulimab
- perampanel
- pexidartinib
- phenobarbital
- phenytoin
- pimavanserin
- pimozide
- pirfenidone
- piroxicam
- pirtobrutinib
- pitolisant
- pomalidomide
- ponatinib
- posaconazole
- pralsetinib
- praziquantel
- prednisolone
- prednisone
- pretomanid
- primidone
- progesterone
- progesterone topical
- propofol
Q
R
- raltegravir
- ramelteon
- ranolazine
- red yeast rice
- regorafenib
- relugolix
- repaglinide
- repotrectinib
- retifanlimab
- revumenib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilpivirine
- rimegepant
- riociguat
- ripretinib
- ritlecitinib
- ritonavir
- rivaroxaban
- roflumilast
- rolapitant
- romidepsin
- ropivacaine
- rosiglitazone
- rosuvastatin
- rucaparib
- ruxolitinib
- ruxolitinib topical
S
- sacituzumab govitecan
- saquinavir
- saxagliptin
- selegiline
- selexipag
- selpercatinib
- selumetinib
- sertraline
- sibutramine
- sildenafil
- silodosin
- simvastatin
- siponimod
- sirolimus
- sirolimus protein-bound
- sofosbuvir
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sonidegib
- sorafenib
- sotorasib
- sparsentan
- st. john's wort
- stiripentol
- sufentanil
- sulfamethoxazole
- sunitinib
- suprofen ophthalmic
- suvorexant
- suzetrigine
T
- tacrolimus
- tadalafil
- tamoxifen
- tamsulosin
- tasimelteon
- tazemetostat
- telaprevir
- telithromycin
- telotristat
- temazepam
- temsirolimus
- teniposide
- tenofovir alafenamide
- tenofovir disoproxil
- tepotinib
- terbinafine
- terfenadine
- testosterone
- testosterone topical
- thiotepa
- tiagabine
- ticagrelor
- tinidazole
- tipranavir
- tislelizumab
- tofacitinib
- tolazamide
- tolbutamide
- tolterodine
- tolvaptan
- topiramate
- toremifene
- toripalimab
- torsemide
- trabectedin
- tramadol
- trazodone
- tremelimumab
- tretinoin
- triamcinolone
- triazolam
- trofinetide
- troglitazone
- troleandomycin
- tucatinib
U
V
- vadadustat
- valbenazine
- valdecoxib
- vamorolone
- vandetanib
- vardenafil
- vemurafenib
- venetoclax
- venlafaxine
- verapamil
- vilazodone
- viloxazine
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- voclosporin
- vonoprazan
- vorapaxar
- vorasidenib
- voriconazole
- vortioxetine
- voxelotor
W
Z
Lorlatinib alcohol/food interactions
There are 3 alcohol/food interactions with lorlatinib.
Lorlatinib disease interactions
There are 8 disease interactions with lorlatinib which include:
- atrioventricular block
- CNS effects
- hepatotoxicity/hepatic impairment
- hyperglycemia
- hyperlipidemia
- hypertension
- interstitial lung disease
- severe renal impairment
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More about lorlatinib
- lorlatinib consumer information
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: multikinase inhibitors
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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