Drug Interactions between lorazepam and Vantin
This report displays the potential drug interactions for the following 2 drugs:
- lorazepam
- Vantin (cefpodoxime)
Interactions between your drugs
No interactions were found between lorazepam and Vantin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
lorazepam
A total of 404 drugs are known to interact with lorazepam.
- Lorazepam is in the following drug classes: benzodiazepine anticonvulsants, benzodiazepines, miscellaneous antiemetics.
- Lorazepam is used to treat the following conditions:
Vantin
A total of 68 drugs are known to interact with Vantin.
- Vantin is in the drug class third generation cephalosporins.
- Vantin is used to treat the following conditions:
Drug and food interactions
cefpodoxime food
Applies to: Vantin (cefpodoxime)
ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of cefpodoxime proxetil tablets. Following a 200 mg dose taken with food, the extent of absorption (mean AUC) was 21% to 33% higher and the mean peak plasma concentration (Cmax) 19% higher than under fasting conditions. Time to peak concentration (Tmax) was not significantly different between fed and fasted states. On the contrary, when a 200 mg dose of the suspension was taken with food, the mean AUC and Cmax were not significantly different than those under fasting conditions, although the rate of absorption was slower with food (48% increase in Tmax ).
MANAGEMENT: To ensure maximal oral absorption, cefpodoxime proxetil tablets should be administered with or immediately after a meal.
References
- Hughes GS, Heald DL, Barker KB, et al. (1989) "The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil." Clin Pharmacol Ther, 46, p. 674-85
- "Product Information. Vantin (cefpodoxime)." Pharmacia and Upjohn
- Borin MT, Driver MR, Forbes KK (1995) "Effect of timing of food on absorption of cefpodoxime proxetil." J Clin Pharmacol, 35, p. 505-9
LORazepam food
Applies to: lorazepam
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
- (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
- (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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