Irinotecan Drug Interactions
Currently displaying a list of 445 drugs known to interact with irinotecan.
- 93 major drug interactions
- 325 moderate drug interactions
- 27 minor drug interactions
Medications known to interact with irinotecan
Note: Showing generic names only.
A
- abametapir topical
- abiraterone
- abrocitinib
- acetazolamide
- adagrasib
- adalimumab
- adenovirus vaccine
- alefacept
- alemtuzumab
- allopurinol
- alpelisib
- amiloride
- aminoglutethimide
- amiodarone
- amobarbital
- amprenavir
- anakinra
- anthrax vaccine adsorbed
- apalutamide
- aprepitant
- armodafinil
- asciminib
- atazanavir
- atezolizumab
- atracurium
- avacopan
- avelumab
- azathioprine
B
- baricitinib
- bcg
- bcg vaccine
- belzutifan
- bempedoic acid
- bendroflumethiazide
- benzthiazide
- berotralstat
- bexarotene
- bicalutamide
- bifidobacterium infantis
- bifidobacterium longum
- bisacodyl
- boceprevir
- bosentan
- brewer's yeast
- brigatinib
- bumetanide
- butabarbital
- butalbital
C
- canakinumab
- candida albicans extract
- capivasertib
- capmatinib
- carbamazepine
- casanthranol
- cascara sagrada
- castor oil
- ceftobiprole medocaril
- cemiplimab
- cenobamate
- ceritinib
- certolizumab
- chikungunya vaccine, live (cvx 317)
- chikungunya vaccine, recombinant (cvx 329)
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chlorothiazide
- chlorthalidone
- cholera vaccine
- cholera vaccine, live
- cimetidine
- cinoxacin
- ciprofloxacin
- cisatracurium
- citalopram
- cladribine
- clarithromycin
- clozapine
- cobicistat
- coccidioidin skin test
- conivaptan
- cosibelimab
- COVID-19 mRNA (Moderna) vaccine
- COVID-19 mRNA (Pfizer) vaccine
- crizotinib
- cyclosporine
D
- dabrafenib
- danicopan
- daridorexant
- darolutamide
- darunavir
- dasatinib
- deferasirox
- deferiprone
- delafloxacin
- delavirdine
- dengue vaccine
- denosumab
- deucravacitinib
- dexamethasone
- dichlorphenamide
- diltiazem
- dimethyl fumarate
- diroximel fumarate
- dostarlimab
- doxacurium
- dronedarone
- durvalumab
- duvelisib
E
- echinacea
- efalizumab
- efavirenz
- efbemalenograstim alfa
- eflapegrastim
- elacestrant
- elafibranor
- elagolix
- eltrombopag
- eluxadoline
- enasidenib
- encorafenib
- enoxacin
- entrectinib
- enzalutamide
- erythromycin
- eslicarbazepine
- etanercept
- ethacrynic acid
- etrasimod
- etravirine
F
- fedratinib
- felbamate
- fenfluramine
- fexinidazole
- filgrastim
- fingolimod
- fluconazole
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosphenytoin
- fostamatinib
- fostemsavir
- furosemide
- futibatinib
G
- ganciclovir
- gatifloxacin
- gemfibrozil
- gemifloxacin
- gilteritinib
- glasdegib
- glycerin
- goldenseal
- golimumab
- grepafloxacin
- griseofulvin
H
- haemophilus b conjugate (hboc) vaccine
- haemophilus b conjugate (prp-omp) vaccine
- haemophilus b conjugate (prp-t) vaccine
- hepatitis a adult vaccine
- hepatitis a pediatric vaccine
- hepatitis b adult vaccine
- hepatitis b pediatric vaccine
- histoplasmin
- human papillomavirus vaccine
- hydrochlorothiazide
- hydroflumethiazide
I
- idelalisib
- imatinib
- indapamide
- indinavir
- infliximab
- influenza virus vaccine, h1n1, inactivated
- influenza virus vaccine, h1n1, live
- influenza virus vaccine, h5n1
- influenza virus vaccine, inactivated
- influenza virus vaccine, live
- ipilimumab
- iptacopan
- isavuconazonium
- isoniazid
- isosorbide
- itraconazole
- ivacaftor
- ivosidenib
J
K
L
- lactitol
- lactobacillus acidophilus
- lactobacillus reuteri
- lactobacillus rhamnosus
- lactobacillus rhamnosus gg
- lactulose
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- leflunomide
- lenacapavir
- leniolisib
- letermovir
- levofloxacin
- levoketoconazole
- lomefloxacin
- lomitapide
- lonafarnib
- lonapegsomatropin
- loncastuximab tesirine
- lorlatinib
- lyme disease vaccine
M
- magnesium citrate
- magnesium hydroxide
- magnesium sulfate
- mannitol
- maribavir
- mavacamten
- mavorixafor
- measles virus vaccine
- meningococcal conjugate vaccine
- meningococcal group acwy conjugate-group b vaccine (cvx 316)
- meningococcal group B vaccine
- meningococcal polysaccharide vaccine
- mephobarbital
- methazolamide
- methyclothiazide
- metocurine
- metolazone
- metreleptin
- mibefradil
- miconazole
- midostaurin
- mifepristone
- mineral oil
- mitapivat
- mitotane
- mivacurium
- mixed respiratory vaccine
- mobocertinib
- modafinil
- momelotinib
- monomethyl fumarate
- moxifloxacin
- mumps skin test antigen
- mumps virus vaccine
N
- nadofaragene firadenovec
- nafcillin
- nalidixic acid
- natalizumab
- nefazodone
- nelfinavir
- neratinib
- nevirapine
- nifedipine
- nilotinib
- niraparib
- nirogacestat
- nivolumab
- norfloxacin
O
- ocrelizumab
- ofloxacin
- olaparib
- olutasidenib
- omacetaxine
- omaveloxolone
- oritavancin
- osilodrostat
- osimertinib
- oteseconazole
- oxaliplatin
- oxcarbazepine
- ozanimod
P
- pacritinib
- palbociclib
- palifermin
- pamabrom
- pancuronium
- panitumumab
- pazopanib
- pegfilgrastim
- pembrolizumab
- pentobarbital
- pertussis, acellular
- pexidartinib
- phenobarbital
- phenolphthalein
- phenylbutazone
- phenytoin
- pipecuronium
- pirtobrutinib
- pitolisant
- plague vaccine
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 23-polyvalent vaccine
- pneumococcal 7-valent vaccine
- poliovirus vaccine, inactivated
- poliovirus vaccine, live, trivalent
- polyethylene glycol 3350
- polythiazide
- ponesimod
- posaconazole
- pralsetinib
- pretomanid
- primidone
- prochlorperazine
R
- rabies vaccine, human diploid cell
- rabies vaccine, purified chick embryo cell
- radium 223 dichloride
- ranolazine
- rapacuronium
- regorafenib
- remdesivir
- repotrectinib
- resmetirom
- retifanlimab
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- ripretinib
- ritlecitinib
- ritonavir
- rocuronium
- roflumilast
- rolapitant
- ropeginterferon alfa-2b
- rotavirus vaccine
- rsv vaccine pref3, recombinant
- rsv vaccine, mrna
- rsv vaccine, pref a-pref b, recombinant
- rubella virus vaccine
- rucaparib
- rufinamide
S
- saccharomyces boulardii lyo
- sacituzumab govitecan
- safinamide
- samarium sm 153 lexidronam
- saquinavir
- sargramostim
- sars-cov-2 (covid-19) ad26 vaccine, recombinant
- sars-cov-2 (covid-19) chadox1 vaccine, recombinant
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 308)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 309)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 310)
- sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant
- sars-cov-2 (covid-19) rs-nanoparticle vaccine, recombinant
- sars-cov-2 mrna (tozinameran 5y-11y) vaccine
- sars-cov-2 mrna (tozinameran 6m-4y) vaccine
- sars-cov-2 mrna (tozinameran-tris-sucrose) vaccine
- sars-cov-2 mrna (tozinameran) vaccine
- sars-cov-2 mrna-1273 (6m-5y) vaccine
- sars-cov-2 mrna-1273 (6y-11y) vaccine
- sars-cov-2 mrna-1273 (booster only) vaccine
- sars-cov-2 nvx-cov2373 vaccine, recomb (cvx 313)
- sars-cov-2 pres dtm (booster only) vaccine, recombinant
- secobarbital
- selpercatinib
- senna
- siponimod
- sipuleucel-T
- sirolimus
- skin test antigens, multiple
- smallpox and mpox vaccine
- smallpox vaccine
- sodium phosphate p32
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sorafenib
- sotorasib
- sparfloxacin
- spironolactone
- st. john's wort
- staphage lysate (spl)
- stiripentol
- streptococcus salivarius
- strontium-89 chloride
- succinylcholine
- sulfinpyrazone
- suvorexant
- suzetrigine
T
- tacrolimus
- tafamidis
- talimogene laherparepvec
- tazemetostat
- tbo-filgrastim
- tecovirimat
- telaprevir
- telithromycin
- telotristat
- temsirolimus
- tepotinib
- teriflunomide
- tetanus toxoid
- thalidomide
- ticagrelor
- tick-borne encephalitis (inactivated) pediatric vaccine
- tick-borne encephalitis (inactivated) vaccine
- tislelizumab
- tofacitinib
- topotecan
- toripalimab
- torsemide
- tovorafenib
- tremelimumab
- treosulfan
- triamterene
- trichlormethiazide
- trichophyton skin test
- trofinetide
- troglitazone
- troleandomycin
- trovafloxacin
- tuberculin purified protein derivative
- tubocurarine
- tucatinib
- typhoid vaccine, inactivated
- typhoid vaccine, live
U
V
- vadadustat
- valganciclovir
- varicella virus vaccine
- vecuronium
- vemurafenib
- verapamil
- viloxazine
- vimseltinib
- vitamin e
- voclosporin
- vorasidenib
- voriconazole
- voxelotor
Y
Z
Irinotecan disease interactions
There are 4 disease interactions with irinotecan which include:
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.