Donepezil Drug Interactions
Currently displaying a list of 527 drugs known to interact with donepezil.
- 12 major drug interactions
- 409 moderate drug interactions
- 106 minor drug interactions
Medications known to interact with donepezil
Note: Showing generic names only.
A
- abametapir topical
- abarelix
- abiraterone
- acebutolol
- acrivastine
- adagrasib
- albuterol
- alectinib
- alfuzosin
- ambenonium
- amifampridine
- aminoglutethimide
- amiodarone
- amisulpride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amprenavir
- anagrelide
- apalutamide
- apomorphine
- aprepitant
- arformoterol
- aripiprazole
- armodafinil
- arsenic trioxide
- asciminib
- asenapine
- aspirin
- astemizole
- atazanavir
- atenolol
- atomoxetine
- atracurium
- atropine
- atropine ophthalmic
- avacopan
- azatadine
- azithromycin
B
- bedaquiline
- belladonna
- belzutifan
- benzgalantamine
- benztropine
- bepridil
- berotralstat
- betamethasone
- betaxolol
- bethanechol
- bexarotene
- bicalutamide
- biperiden
- bismuth subsalicylate
- bisoprolol
- bitolterol
- boceprevir
- bosentan
- bosutinib
- brexpiprazole
- brigatinib
- bromfenac
- brompheniramine
- budesonide
- buprenorphine
- bupropion
- butabarbital
- butalbital
C
- cabozantinib
- capivasertib
- carbamazepine
- carbinoxamine
- carteolol
- carvedilol
- celecoxib
- cenobamate
- ceritinib
- chloramphenicol
- chlorcyclizine
- chloroquine
- chlorpheniramine
- chlorpromazine
- choline salicylate
- cilostazol
- cimetidine
- cinacalcet
- ciprofloxacin
- cisapride
- cisatracurium
- citalopram
- clarithromycin
- clemastine
- clevidipine
- clidinium
- clobazam
- clofazimine
- clomipramine
- clotrimazole
- clozapine
- cobicistat
- conivaptan
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- crizotinib
- cyclizine
- cyclobenzaprine
- cyclopentolate ophthalmic
- cyclosporine
- cyproheptadine
D
- dabrafenib
- dacomitinib
- danazol
- daridorexant
- darifenacin
- darunavir
- dasatinib
- daunorubicin
- daunorubicin liposomal
- deferasirox
- deflazacort
- degarelix
- delavirdine
- desipramine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- diclofenac
- dicyclomine
- diflunisal
- digitoxin
- digoxin
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- dofetilide
- dolasetron
- doxacurium
- doxepin
- doxepin topical
- doxorubicin
- doxorubicin liposomal
- doxylamine
- dronedarone
- droperidol
- duloxetine
- duvelisib
E
- echinacea
- edrophonium
- efavirenz
- elafibranor
- elagolix
- eliglustat
- encorafenib
- entrectinib
- enzalutamide
- epirubicin
- eribulin
- erythromycin
- escitalopram
- eslicarbazepine
- esmolol
- etodolac
- etrasimod
- etravirine
- evening primrose
- everolimus
- ezogabine
F
- famotidine
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenoprofen
- fexinidazole
- fingolimod
- flavoxate
- flecainide
- fluconazole
- fludrocortisone
- fluoxetine
- fluphenazine
- flurbiprofen
- flutamide
- fluvoxamine
- formoterol
- fosamprenavir
- fosaprepitant
- foscarnet
- fosphenytoin
- fostamatinib
- fostemsavir
G
- galantamine
- gatifloxacin
- gefitinib
- gemifloxacin
- gepirone
- gilteritinib
- ginkgo
- givinostat
- givosiran
- glasdegib
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- goldenseal
- goserelin
- granisetron
- grepafloxacin
- griseofulvin
- guanidine
H
- halofantrine
- haloperidol
- halothane
- histrelin
- homatropine ophthalmic
- hydrocortisone
- hydroxychloroquine
- hydroxyzine
- hyoscyamine
I
- ibuprofen
- ibutilide
- idarubicin
- idelalisib
- iloperidone
- imatinib
- imipramine
- indacaterol
- indinavir
- indomethacin
- inotuzumab ozogamicin
- iohexol
- iomeprol
- iopamidol
- iptacopan
- isavuconazonium
- isoetharine
- isoniazid
- isoproterenol
- isradipine
- itraconazole
- ivabradine
- ivacaftor
- ivosidenib
K
L
- labetalol
- lacosamide
- landiolol
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- lenvatinib
- letermovir
- leuprolide
- levalbuterol
- levamlodipine
- levofloxacin
- levoketoconazole
- levomethadyl acetate
- lindane topical
- lisdexamfetamine
- lithium
- lofexidine
- lomefloxacin
- lomitapide
- lonafarnib
- lonapegsomatropin
- loperamide
- lorcaserin
- lorlatinib
- loxapine
- lumateperone
M
- macimorelin
- magnesium salicylate
- maprotiline
- mavacamten
- mavorixafor
- meclizine
- meclofenamate
- mefenamic acid
- mefloquine
- meloxicam
- mepenzolate
- mephobarbital
- mesoridazine
- metaproterenol
- methacholine
- methadone
- methdilazine
- methotrimeprazine
- methscopolamine
- methylprednisolone
- metocurine
- metoprolol
- metrizamide
- metronidazole
- mibefradil
- miconazole
- midostaurin
- mifepristone
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mivacurium
- mobocertinib
- modafinil
- molindone
- moricizine
- moxifloxacin
N
- nabumetone
- nadolol
- nafcillin
- naproxen
- nebivolol
- nefazodone
- nelfinavir
- neostigmine
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nilutamide
- nimodipine
- nirogacestat
- nisoldipine
- norfloxacin
- nortriptyline
O
- ofloxacin
- olanzapine
- oliceridine
- olodaterol
- olutasidenib
- omaveloxolone
- ondansetron
- oritavancin
- orphenadrine
- osilodrostat
- osimertinib
- oxaliplatin
- oxamniquine
- oxaprozin
- oxcarbazepine
- oxybutynin
- oxytocin
- ozanimod
P
- pacritinib
- palbociclib
- paliperidone
- palonosetron
- pancuronium
- panobinostat
- papaverine
- paroxetine
- pasireotide
- pazopanib
- penbutolol
- pentamidine
- pentobarbital
- perflutren
- perphenazine
- pexidartinib
- phenindamine
- phenobarbital
- phenylbutazone
- phenytoin
- physostigmine
- pilocarpine
- pimavanserin
- pimozide
- pindolol
- pipecuronium
- pirbuterol
- piroxicam
- pirtobrutinib
- pitolisant
- polyethylene glycol 3350 with electrolytes
- ponesimod
- posaconazole
- pralsetinib
- prednisolone
- prednisone
- primaquine
- primidone
- probucol
- procainamide
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propantheline
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pyridostigmine
- pyrilamine
Q
R
- ramelteon
- ranitidine
- ranolazine
- rapacuronium
- relugolix
- remdesivir
- repotrectinib
- revumenib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilpivirine
- risperidone
- ritlecitinib
- ritodrine
- ritonavir
- rivastigmine
- rizatriptan
- rocuronium
- rolapitant
- romidepsin
- rucaparib
S
- salmeterol
- salsalate
- saquinavir
- scopolamine
- scopolamine ophthalmic
- secobarbital
- selpercatinib
- sertraline
- sevoflurane
- siponimod
- sodium salicylate
- sofpironium topical
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sorafenib
- sotalol
- sotorasib
- sparfloxacin
- st. john's wort
- stiripentol
- succinylcholine
- sulfinpyrazone
- sulindac
- sunitinib
- suvorexant
- suzetrigine
T
- tacrine
- tamoxifen
- tazemetostat
- tebentafusp
- tecovirimat
- telaprevir
- telavancin
- telithromycin
- telotristat
- terbinafine
- terbutaline
- terfenadine
- tetrabenazine
- thalidomide
- thiethylperazine
- thioridazine
- thiothixene
- ticlopidine
- timolol
- tizanidine
- tofacitinib
- tolmetin
- tolterodine
- toremifene
- tovorafenib
- tramadol
- trazodone
- treosulfan
- triamcinolone
- triamcinolone ophthalmic
- triclabendazole
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimipramine
- tripelennamine
- triprolidine
- triptorelin
- trofinetide
- troglitazone
- troleandomycin
- tropicamide ophthalmic
- trospium
- tubocurarine
- tucatinib
V
- vadadustat
- valbenazine
- vamorolone
- vandetanib
- vardenafil
- vasopressin
- vecuronium
- vemurafenib
- venlafaxine
- verapamil
- viloxazine
- voclosporin
- vonoprazan
- vorasidenib
- voriconazole
- voxelotor
Z
Donepezil disease interactions
There are 8 disease interactions with donepezil which include:
- bradycardia
- bronchospasm
- coronary artery disease
- parkinsonism
- hyperthyroidism
- PUD
- seizures
- hepatic dysfunction
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More about donepezil
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- Reviews (142)
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- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: cholinesterase inhibitors
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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