Dextromethorphan/phenylephrine Interactions
There are 518 drugs known to interact with dextromethorphan/phenylephrine, along with 4 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 87 are major, 428 are moderate, and 3 are minor.
- View all 518 medications that may interact with dextromethorphan/phenylephrine
- View dextromethorphan/phenylephrine alcohol/food interactions (1)
- View dextromethorphan/phenylephrine disease interactions (4)
Most frequently checked interactions
View interaction reports for dextromethorphan / phenylephrine and the medicines listed below.
- Abilify (aripiprazole)
- Acid Reducer-Famotidine (famotidine)
- Advair Diskus (fluticasone / salmeterol)
- Advil (ibuprofen)
- Advil Cold and Sinus (ibuprofen / pseudoephedrine)
- Afrin (oxymetazoline nasal)
- Alcohol (contained in alcoholic beverages) (ethanol)
- Allegra (fexofenadine)
- Allegra Allergy (fexofenadine)
- Bactrim DS (sulfamethoxazole / trimethoprim)
- Bayer Aspirin (aspirin)
- Benadryl (diphenhydramine)
- Breztri Aerosphere (budesonide / formoterol / glycopyrrolate)
- Cambia (diclofenac)
- Children's Tylenol (acetaminophen)
- Clarinex (desloratadine)
- Combivent Respimat (albuterol / ipratropium)
- Cotrim (sulfamethoxazole / trimethoprim)
- Curcuplex-95 (turmeric)
- Cymbalta (duloxetine)
- Delsym 12 Hour Cough Relief (dextromethorphan)
- Eliquis (apixaban)
- Flexeril (cyclobenzaprine)
- Imodium (loperamide)
- Paracetamol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin B6 (pyridoxine)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Zinc (zinc sulfate)
Dextromethorphan/phenylephrine alcohol/food interactions
There is 1 alcohol/food interaction with dextromethorphan / phenylephrine.
Dextromethorphan/phenylephrine disease interactions
There are 4 disease interactions with dextromethorphan / phenylephrine which include:
Report options
More about dextromethorphan / phenylephrine
- dextromethorphan/phenylephrine consumer information
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Dextromethorphan/guaifenesin/phenylephrine
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.