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Dextromethorphan / guaifenesin Drug Interactions

A total of 622 drugs are known to interact with dextromethorphan / guaifenesin.

  • 99 major drug interactions
  • 520 moderate drug interactions
  • 3 minor drug interactions

Show all medications in the database that may interact with dextromethorphan / guaifenesin.

Check for interactions

Type in a drug name to check for interactions with dextromethorphan / guaifenesin.

Most frequently checked interactions

View interaction reports for dextromethorphan / guaifenesin and the medicines listed below.

  • acetaminophen (Tylenol, Paracetamol, Panadol, Mapap, Tylenol Arthritis Pain, Tylenol Extra Strength, Ofirmev, Children's Tylenol, Arthritis Pain Relief, Perfalgan, Doliprane, Efferalgan, Paracetamol Teva, Tempra, Cipla Genpharm Paracetamol, Dafalgan, Tactinal, Altenol, Feverall, Panadol ActiFast, Panamax, Panadol Osteo, Mapap Arthritis Pain, Panadol Extend, Lemsip Max, Paracetamol Almus, Paracetamol Ranbaxy, Promax, Tylenol 8 Hour, Aceta, Acephen, Dolono, Infant's Tylenol, Calpol Paediatric, Cetafen, Panadol Gel Tabs, Setamol, Blooms the Chemist Paracetamol, Panadol Childrens, Buckley's Complete, Pharbetol, Doliprane Adultes, Efferalgan Pediatrique, Paracetamol Ivax, Actamin, BF-Paradac, Paracetamol Sandoz Conseil, Tycolene, Q-Pap, Atasol, Triaminic Infant Drops, Mapap Extra Strength Rapid Burst, Disprol Soluble Paracetamol, Calpol Infant, Alvedon, Calpol Fastmelts, Aminofen, Anadin Paracetamol, Hedex, Valorin, Parmol, Orajel Maximum Strength Toothache, RP Scherer Paracetamol, Terry White Chemists Paracetamol, Pharmacist Advice Paracetamol, Terry White Chemists Paracetamol Colourfree Children 5-12 Years, Paracare, Tylenol Childrens Paracetamol, Conney Aspirin-Free, Priceline Paracetamol, Panadol Gel Caps, Pacimol Caplets, Pharmore Paracetamol, Tylophen, Basics Paracetamol, Genapap, Sigma Pain Relief, Pain Clear Paracetamol, Paraspen Drops, Panadol Colourfree Drops, Pharmacist Paracetamol Infant Drops, Pharmacist Paracetamol Infant Drops Colour Free, Bi-Lo Paracetamol, Pain-Eze Paracetamol Infant Drops Colour Free, Pharmaction Paracetamol, Biochemie Paracetamol, Healthsense Pain Relief Drops Children 1 Month to 2 Years, Black And Gold Paraceatmol, Pharmacist Advice Paracetamol Infant Drops, Black and Gold Paracetamol, Hexal Comfarol, Abenol, Paracetamol Soluble, Vitapap, Bristol Pharma Paracetamol, Sigma Paracetamol, Actimol Infant, ConRx Extra Strength, PediaCare Infants' Acetaminophen Fever Reducer/Pain Reliever, PediaCare Children's Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Childrens, PediaCare Smooth Melts Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Infants and Childrens Drops 1 Month-4 Years, Mapap Children's, Capital Chemist Paracetamol, Lemsip Cold and Flu Liquid Capsule, Children's Silapap, Febrol Solution, Pharmacy Health Own Name Paracetamol for Children, Febridol Infant Drops, Accidental Rapatabs, Chem Mart Chemadol Children 1 to 5 Years, Chem Mart Chemadol Colourfree, Chem Mart Chemadol Colourfree Children 5-12 Years, Chemists Own Chiildrens Paracetamol 5-12 Years, Lemsip Headcold, Chemists Own Childrens Paracetamol 1-5 Years, Chemists Own Paracetamol, Lemsip Original, Chemists Own Paracetamol Capseals, Chemists Own Paracetamol Pain & Fever 1 Month to 2 Years, Chemists Own Paracetamol Pain & Fever 1 to 5 Years, Chemists Own Paracetamol Pain and Fever 5 to 12 Years, A-Pak Laboratories Paediatric Analgesic Paracetamol, Chemplus Paracetamol, Chemworld Colourfree Childrens Paracetamol Double Strength 5-12 Years, Chemworld Colourfree Childrens Paracetamol Junior 1-5 Years, Chemworld Paracetamol, Chemworld Paracetamol Infant Colour Free, HyVee Health 8 Hour Pain Relief, Bydol, Chem Mart Chemadol, Leader 8 Hour Pain Reliever, Children's ElixSure, Little Fevers, Mapap Rapid Release Gelcaps, Benylin Sore Throat, Fawns & McAllan Paracetamol, Zee Unaspirin ES, Chem Mart Chemadol Colourfree Childrens 1-5 Years, Midol Long Lasting Relief, Childrens Panadol 1 - 5 Years Colourfree, Childrens Panadol 1 - 5 Years, Childrens Panadol 5 - 12 Years Colourfree, Childrens Panadol 5 - 12 Years, Equaline Pain Relief, Help I Have A Headache, Febridol Clear Effervescent, Herron Paracetamol Tabsules, Panadol Rapid Handipak, Panadol Soluble, Paralgin Paracetamol Tabsules, Pharmacist Childrens Paracetamol Colourfree 1-5 Years, Pharmacist Childrens Paracetamol Colourfree 5-12 Years, Pharmacy Health Colour Free Childrens Paracetamol, Gold Cross Paracetamol, Tylenol Cold Sore Throat, Alpha First Aid Supplies Paracetamol, Guardian Childrens Paracetamol 5-12 Years, Guardian Paracetamol, Guardian Paracetamol Tabsules, Rex Paracetamol, Topcare Arthritis Pain Relief, Accidental First Aid Supplies Paracetamol, Panadol Jr, Flu Strength Hot Lemon Powders, Paineze Paracetamol, Health Care Chemist Paracetamol Infant Drops Colour Free, Genebs, Herron Gold Paracetamol Tabsules, Tylenol Regular Strength, Panamol, Herron Paracetamol, Tempra 2, Tempol, Herron Paracetamol Capseals, Tempra 3, Taminol, Herron Paracetamol Capseals Handy Pack, Herron Paracetamol Handy Pack, Apra, Q-Nol, Claradol, Anacin Aspirin Free, Conacetol, Coles Paracetamol, Genapap Extra Strength, Doliprane Sans Sucre, Dolitabs, Home Brand Paracetamol, Q-Pap Extra Strength, Dolko, ICN Paracetamol, Redutemp, Dolko Enfants, Dolotec, Vicks Formula 44 Custom Care Body Aches, James Dean Pharmacy Paracetamol, Pain-Eze, Uniserts, Efferalganodis, Silapap Childrens, Expandox, Dolono Infant, Geluprane, Paracetamol Arrow, Paracetamol Biogaran, Ed-APAP, Paracetamol EG, St. Joseph Aspirin-Free, Country Chemists Paracetamol, Paracetamol Merck, Liquiprin, Paracetamol Qualimed, Adprin B, Paracetamol RPG, DG Health Pain Reliever, Tempra Quicklets, Paracetamol Sandoz, Lloydspharmacy Paracetamol Six Plus, Paracetamol Winthrop, Triaminic Fever Reducer Pain Reliever, Lloydspharmacy Paracetamol Infant, Paracetamol Zydus, Atasol Forte, Paralyoc, Tylenol Cool Caplet Extra Strength, Perfalgan Nourrissons Et Enfants, Acetaminophen-odan, Mapap Rapid Tabs, Jr. Tylenol, Elixsure Fever/Pain, Infadrops, Disprol Paracetamol, Galpamol, Paldesic, Medinol Paediatric, Medinol Under 6, Infantaire Drops, Lemsip Pharmacy Non-Decongestant Formula, Calpol Six Plus, Masophen, Medinol Over 6, Nortemp Children's, Paracets, UN-Aspirin Extra Strength, Mandanol, Actimol Children's, Dakota Paracetamol, Miradol, Umphamol, Remedol, Panamax 240, Paralgin, Parahexal, Febridol, Mid West Products Numol Paracetamol, Silapap Infants, Cuprofen for Children, Mapap Infant Drops, Mandanol Infant, Cetafen Extra, Mandanol 6+, Lemsip Childrens Cold & Flu, Fennings Childrens Cooling, Duatrol SR, Aldi Hedanol Paracetamol, Under Ten Care Infant, Alphapharm Paracetamol, Amadol Paracetamol, No Frills Paracetamol, Tylenol Sore Throat Daytime, Nova Paracetamol, Mapap Meltaway, Numark Paracetamol, Amcal Childrens Paracetamol 1-5 Years, Nyal Paracetamol, Medi-Tabs, Amcal Childrens Paracetamol 5-12 Years, Amcal Paracetamol Pain Relief, Ordov Febrigesic Paracetamol, Topcare 8 Hour Pain Relief, Amcal Paracetamol Infant Drops 1 Month to 2 Years, Pain-Eze Paracetamol Infant Drops, Febridol Syrup for Children, Amcal Paracetamol Tabsules, Pharmacist Advice Colourfree Childrens Paracetamol Double Strength, Guardian Childrens Paracetamol, Pharmacist Formula Paracetamol, Pharmacist Formula Infants, Paraspen, RP Scherer Paracetamol Liquid-Filled Capsules, Savings Paracetamol, Signature Range Paracetamol, Dymadon, Soul Pattinson Childrens Paracetamol Elixir, Soul Pattinson Colour Free Paracetamol 1-5 Years, Soul Pattinson Colour Free Paracetamol Drops, Soul Pattinson Colourfree Childrens Paracetamol, API Healthcare Coloufree Childrens Paracetamol, Soul Pattinson Paracetamol, API Healthcare Colourfree Childrens Paracetamol Double Strength, Soul Pattinson Paracetamol Clear Effervescent, Panadol Mini Caps, API Healthcare Paracetamol, Pharmacy Health Paracetamol, Terry White Chemists Colour Free Paracetamol 1-5 Years, Pharmacist Paracetamol, Terry White Chemists Colour Free Paracetamol Infant Drops)
  • Advair Diskus (fluticasone / salmeterol)
  • Aspirin Low Strength (aspirin)
  • Benadryl (diphenhydramine)
  • CoQ10 (ubiquinone)
  • dextromethorphan (Delsym, Dextromethorphan HBr Adult Formula, Delsym 12 Hour Cough Relief, Cough Syrup DM, Dry Cough, Benylin DM, Robitussin CoughGels Long-Acting, Bisolvon Dry, Calmylin, St. Joseph Cough Suppressant, Sucrets Cough, Vicks Formula 44, Delsym 12 Hour Cough Relief for Children & Adults, Strepsils Cough, Creomulsion, Buckley's DM, Hold, DexAlone, PediaCare Children's Long-Acting Cough, Vicks Dayquil Cough, Babee Cof, Silphen DM, Pertussin DM, Vicks Formula 44 Custom Care Dry Cough Suppressant, Balminil DM, Novahistine DM, Covonia Bronchial Balsam, Robitussin Cough Long-Acting, Triaminic Thin Strips Long Acting Cough, Benadryl for the Family Dry Forte, Theraflu Thin Strips Cough, Neocitran Thin Strips Cough, Contac Cough, Robafen Cough Liquidgels, Jack & Jill Thin Strips Cough, Tussinol for Dry Coughs, Bisolvon Dry Junior, Dristan DM, Dexi-Tuss, Nucosef DM, Strepsils Cough Relief, Delsym Children's 12-Hour Cough Relief, Buckleys Mixture, Pedia Relief, Triaminic Long Acting Cough, Creomulsion Children, Buckley's Mixture Cough Suppressant, Tussin Cough Gels (Long Acting), Vicks Nature Fusion Cough, Duract Max Strength Cough, Scot-Tussin Diabetes, Lloydspharmacy Dry Adult Cough, 12 Hour Cough Relief, Triaminic Thin Strips Cough, Robitussin 12-Hour Cough Relief, ElixSure Cough, Scot-Tussin DM Cough Chasers, Hold DM, Pertussin CS Childrens, Robitussin Children's Cough Long-Acting, Pertussin ES, Tussin Pediatric, Robafen Pediatric Cough & Cold)
  • Dulcolax Stool Softener (docusate)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • Gas-X (simethicone)
  • guaifenesin / phenylephrine (Deconex, Entex LA, Gilphex TR, Endal, Aldex, Guaiphen-PD, Despec, Xpect-PE, Duomax, Miraphen PE, Triaminic Chest & Nasal Congestion, Refenesen Chest Congestion Relief PE, Mydex, Nazarin, Mucus Relief Sinus, Supress-PE, Chest Congestion Relief PE, Mucus Relief PE, Prolex D, Crantex, Guaiphen-D 600, Guaiphen-D 1200, Donatussin Drops, Simuc, Zotex GPX, Guaifen PE, Norel EX, Aldex G, Nexphen PD, Reluri, Nariz, Duraphen 1000, Lusonex, Dynex LA, Sudex, Extendryl G, Rescon-GG, Maxiphen, Guaphenyl LA, MontePhen, Gentex LA, Xedec II, Liquibid-D, Simuc-GP, Zotex-GP, Duratuss PE, Sitrex PD, Medent-PE, Genexa LA, Ambi 40/1000, J-Max, Medent-PEI, D-Phen 1000, Mucinex Children's Stuffy Nose & Cold, Visonex, Deconex IR, Guiadex PD, Guiatex PE, Entex LQ, Aquatab D, Respa-PE, Sudafed PE Non-Drying Sinus, Liquibid D-R, Liquibid PD-R, Relcof IR, Lusair, D-Tab, ExeTuss, ExeTuss-GP, MucaphEd, Fenesin PE IR, Reese Onetab Congestion & Cough, Nu-COPD, Dimetapp Children's Cold & Chest Congestion, Zyrphen, PE-Guai, Tussi-Pres PE, Sinupan, Deconsal Pediatric, Efasin, Amidal, Chemdal, Quindal, SINUvent PE, Crantex LA Capsules, Amitex LA, Entex ER, Duraphen II, Liquibid-PD, Crantex ER, Liquibid-D 1200, Phenavent LA, Quintex, Phenavent D, Deconsal II, Guaifed Caps, Guaifed PD, Sina-12X, Phenavent, Tussbid, Phenavent PED, Nescon-PD, Pendex, Prolex PD, Duravent PE, Nasex, Crantex LA Tablets, ED Bron GP, Duratuss, Duratuss GP, Sitrex, Wellbid-D, Wellbid-D 1200, Xedec, Nasex-G)
  • Lipitor (atorvastatin)
  • Naprosyn (naproxen)
  • Nexium (esomeprazole)
  • phenylephrine (Neo-Synephrine, Sudafed PE Congestion, Suphedrine PE, Nasal Decongestant PE, Help I Have A Stuffy Nose, Sudogest PE, Dimetapp Toddler's Drops Decongestant, Vazculep, Sudafed PE Children's Nasal Decongestant, Despec-SF, Nasop12, Triaminic Thin Strips Cold with Stuffy Nose, Phenyl-T, Congest Aid II, AH-Chew D, Gilchew IR, Little Colds Decongestant, Lusonal, Contac-D, Nasop, Ricobid-D, PediaCare Children's Decongestant)
  • pseudoephedrine (Sudafed Congestion, Sudafed 12-Hour, SudoGest, Entex, Sudafed 24-Hour, Silfedrine, Sudafed Children's Nasal Decongestant, Contac Cold, Suphedrin, Chlor-Trimeton Nasal Decongestant, Nexafed Nasal Decongestant, nasofed, Suphedrine, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Decofed Liquid, Efidac, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant)
  • Tylenol (acetaminophen)
  • Tylenol Arthritis Pain (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D2 (ergocalciferol)
  • Vitamin D3 (cholecalciferol)
  • Wellbutrin (bupropion)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Dextromethorphan / guaifenesin alcohol/food interactions

There is 1 alcohol/food interaction with dextromethorphan / guaifenesin

Dextromethorphan / guaifenesin disease interactions

There is 1 disease interaction with dextromethorphan / guaifenesin:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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