Can you take Claritin with Dextromethorphan / guaifenesin?
No drug interactions found, but 4 warnings to review for the following 2 drugs:
- Claritin (loratadine)
- dextromethorphan/guaifenesin
Drug interactions
There were no interactions found between Claritin and dextromethorphan / guaifenesin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
dextromethorphan Food/Lifestyle
Applies to: dextromethorphan / guaifenesin
Alcohol can increase the nervous system side effects of dextromethorphan such as:
- dizziness
- drowsiness
- difficulty concentrating
Some people may also experience impairment in thinking and judgment.
You should avoid or limit the use of alcohol while being treated with dextromethorphan.
Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you.
Talk to your doctor or pharmacist if you have any questions or concerns.
Minor food/lifestyle interactions
Minor:
loratadine Food/Lifestyle
Applies to: Claritin (loratadine)
Theoretically, grapefruit juice may increase the plasma concentrations of loratadine as it does other drugs that are substrates of the CYP450 3A4 enzymatic pathway. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The clinical significance of this potential interaction is unknown. Reported interactions with potent CYP450 3A4 inhibitors like clarithromycin, erythromycin and ketoconazole have produced substantial increases in the area under the plasma concentration-time curve (AUC) of loratadine and its active metabolite, descarboethoxyloratadine, without associated changes in the overall safety profile of the drug.
The information above is from our professional interaction data. Consumer information is not available for this interaction.
Disease interactions
2 potential interactions Applies to: 2 conditions, including Liver Disease and Renal Dysfunction.
Liver Disease
Moderate:
Claritin
The loratadine in Claritin has a moderate potential interaction with Liver Disease.
Loratadine is primarily converted by the liver to an active metabolite, and both parent drug and metabolite are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from loratadine due to drug and metabolite accumulation. The manufacturer recommends one-half the regular dosage initially in patients with liver failure or decreased renal function (GFR < 30 mL/min). Due to the differential effects of hepatic impairment on the serum half-life and clearance of loratadine and pseudoephedrine, the use of products containing a fixed combination of these drugs is not recommended in the presence of liver failure.
Renal Dysfunction
Moderate:
Claritin
The loratadine in Claritin has a moderate potential interaction with Renal Dysfunction.
Loratadine is primarily converted by the liver to an active metabolite, and both parent drug and metabolite are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from loratadine due to drug and metabolite accumulation. The manufacturer recommends one-half the regular dosage initially in patients with liver failure or decreased renal function (GFR < 30 mL/min). Due to the differential effects of hepatic impairment on the serum half-life and clearance of loratadine and pseudoephedrine, the use of products containing a fixed combination of these drugs is not recommended in the presence of liver failure.
Report options
More resources
Claritin
A total of 123 drugs are known to interact with Claritin.
- Claritin is in the drug class antihistamines.
- Claritin is used to treat the following conditions:
dextromethorphan / guaifenesin
A total of 377 drugs are known to interact with dextromethorphan / guaifenesin.
- Dextromethorphan / guaifenesin is in the drug class upper respiratory combinations.
- Dextromethorphan / guaifenesin is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.