Drug Interactions between cyclobenzaprine and Lorzone
This report displays the potential drug interactions for the following 2 drugs:
- cyclobenzaprine
- Lorzone (chlorzoxazone)
Interactions between your drugs
No interactions were found between cyclobenzaprine and Lorzone. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
cyclobenzaprine
A total of 440 drugs are known to interact with cyclobenzaprine.
- Cyclobenzaprine is in the drug class skeletal muscle relaxants.
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Cyclobenzaprine is used to treat the following conditions:
- Back Pain
- Chronic Myofascial Pain (off-label)
- Fibromyalgia (off-label)
- Migraine (off-label)
- Muscle Spasm
- Pain
- Sciatica
- Temporomandibular Joint Disorder (off-label)
Lorzone
A total of 363 drugs are known to interact with Lorzone.
- Lorzone is in the drug class skeletal muscle relaxants.
- Lorzone is used to treat Muscle Spasm.
Drug and food interactions
chlorzoxazone food
Applies to: Lorzone (chlorzoxazone)
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents such as chlorzoxazone. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills. In addition, in one small study, watercress was reported to increase chlorzoxazone peak concentrations, AUC, and half-life. The proposed mechanism is inhibition of CYP450 2E1 metabolism. The clinical significance is unknown.
MANAGEMENT: Patients receiving chlorzoxazone should be advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how chlorzoxazone affects them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities. Watercress should be avoided if an interaction is suspected; e.g., excess sedation, nausea, or headache occurs.
References
- Leclercq I, Desager JP, Horsmans Y (1998) "Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress." Clin Pharmacol Ther, 64, p. 144-9
cyclobenzaprine food
Applies to: cyclobenzaprine
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
- (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
- (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Muscle relaxants
Therapeutic duplication
The recommended maximum number of medicines in the 'muscle relaxants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'muscle relaxants' category:
- cyclobenzaprine
- Lorzone (chlorzoxazone)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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