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Drug Interactions between afamitresgene autoleucel and dexamethasone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

dexAMETHasone afamitresgene autoleucel

Applies to: dexamethasone and afamitresgene autoleucel

GENERALLY AVOID: The use of systemic corticosteroids may reduce the efficacy of afamitresgene autoleucel, an autologous T-cell immunotherapy agent. The exact mechanism by which corticosteroids exert this effect is not clearly described; however, it may involve corticosteroid-induced T lymphocyte apoptosis. The clinical trial that evaluated the efficacy of afamitresgene autoleucel excluded patients who were on systemic corticosteroids for at least 14 days prior to leukapheresis and lymphodepletion. Therefore, clinical data examining the use of systemic corticosteroids prior to or during an infusion of afamitresgene autoleucel are not available.

MANAGEMENT: The manufacturer of afamitresgene autoleucel recommends avoiding the prophylactic use of systemic corticosteroids. Consultation with institutional protocols, national guidelines, and package labeling may be helpful.

References (3)
  1. Herold MJ, McPherson KG, Reichardt HM (2024) Glucocorticoids in T cell apoptosis and function. https://link.springer.com/article/10.1007/s00018-005-5390-y
  2. Landwehr LS, Altieri B, Schreiner J, et al. (2020) "Interplay between glucocorticoids and tumor-infiltrating lymphocytes on the prognosis of adrenocortical carcinoma." J Immunother Cancer, 8, e000469
  3. (2024) "Product Information. Tecelra (afamitresgene autoleucel)." Adaptimmune, LLC

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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