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Acetaminophen / pseudoephedrine Drug Interactions

A total of 455 drugs are known to interact with acetaminophen / pseudoephedrine.

  • 52 major drug interactions
  • 317 moderate drug interactions
  • 86 minor drug interactions

Show all medications in the database that may interact with acetaminophen / pseudoephedrine.

Check for interactions with acetaminophen / pseudoephedrine

Type in a drug name and select a drug from the list.

Common medications checked in combination with acetaminophen / pseudoephedrine

  • acetaminophen (Tylenol, Paracetamol, Panadol, Mapap, Tylenol Arthritis Pain, Tylenol Extra Strength, Ofirmev, Perfalgan, Children's Tylenol, Doliprane, Panadol Osteo, Arthritis Pain Relief, Tempra, Paracetamol Almus, Dafalgan, Cipla Genpharm Paracetamol, Paracetamol Teva, Infant's Tylenol, Liquiprin, Aminofen, Panadol ActiFast, Mapap Arthritis Pain, Promax, Priceline Paracetamol, Tylenol 8 Hour, Abenol, Altenol, Febrol Solution, Pharmacy Health Own Name Paracetamol for Children, Chemists Own Paracetamol Pain & Fever 1 Month to 2 Years, Little Fevers, Aceta, Feverall, Buckley's Complete, Panamol, Pharbetol, Q-Nol, Anacin Aspirin Free, Efferalgan, Pain-Eze, Paracetamol Arrow, Paracetamol Biogaran, Actamin, DG Health Pain Reliever, Paracetamol Sandoz, Tycolene, Q-Pap, Atasol, Perfalgan Nourrissons Et Enfants, Calpol Infant, Alvedon, Calpol Fastmelts, Miradol, Remedol, Panamax, Paralgin, Febridol, Lemsip Childrens Cold & Flu, Terry White Chemists Paracetamol, Pharmacist Advice Paracetamol, Terry White Chemists Paracetamol Colourfree Children 5-12 Years, Paracare, Tylenol Childrens Paracetamol, Conney Aspirin-Free, Panadol Gel Caps, Pacimol Caplets, Pharmore Paracetamol, Tylophen, Basics Paracetamol, Genapap, Sigma Pain Relief, Pain Clear Paracetamol, Setamol, Paraspen Drops, Panadol Colourfree Drops, Pharmacist Paracetamol Infant Drops, Pharmacist Paracetamol Infant Drops Colour Free, Bi-Lo Paracetamol, Pain-Eze Paracetamol Infant Drops Colour Free, Pharmaction Paracetamol, Biochemie Paracetamol, Healthsense Pain Relief Drops Children 1 Month to 2 Years, Black And Gold Paraceatmol, Pharmacist Advice Paracetamol Infant Drops, Black and Gold Paracetamol, Hexal Comfarol, Blooms the Chemist Paracetamol, Panadol Extend, Paracetamol Soluble, Vitapap, Bristol Pharma Paracetamol, Sigma Paracetamol, Actimol Infant, ConRx Extra Strength, PediaCare Infants' Acetaminophen Fever Reducer/Pain Reliever, PediaCare Children's Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Childrens, PediaCare Smooth Melts Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Infants and Childrens Drops 1 Month-4 Years, Mapap Children's, Capital Chemist Paracetamol, Lemsip Cold and Flu Liquid Capsule, Children's Silapap, Febridol Infant Drops, Accidental Rapatabs, Chem Mart Chemadol Children 1 to 5 Years, Chem Mart Chemadol Colourfree, Chem Mart Chemadol Colourfree Children 5-12 Years, Chemists Own Chiildrens Paracetamol 5-12 Years, Lemsip Headcold, Chemists Own Childrens Paracetamol 1-5 Years, Lemsip Max, Chemists Own Paracetamol, Lemsip Original, Chemists Own Paracetamol Capseals, Chemists Own Paracetamol Pain & Fever 1 to 5 Years, Chemists Own Paracetamol Pain and Fever 5 to 12 Years, A-Pak Laboratories Paediatric Analgesic Paracetamol, Chemplus Paracetamol, Chemworld Colourfree Childrens Paracetamol Double Strength 5-12 Years, Chemworld Colourfree Childrens Paracetamol Junior 1-5 Years, Chemworld Paracetamol, Chemworld Paracetamol Infant Colour Free, HyVee Health 8 Hour Pain Relief, Bydol, Chem Mart Chemadol, Leader 8 Hour Pain Reliever, Children's ElixSure, Mapap Rapid Release Gelcaps, Benylin Sore Throat, Fawns & McAllan Paracetamol, Zee Unaspirin ES, Chem Mart Chemadol Colourfree Childrens 1-5 Years, Midol Long Lasting Relief, Childrens Panadol 1 - 5 Years Colourfree, Childrens Panadol 1 - 5 Years, Childrens Panadol 5 - 12 Years Colourfree, Childrens Panadol 5 - 12 Years, Equaline Pain Relief, Help I Have A Headache, Febridol Clear Effervescent, Herron Paracetamol Tabsules, Panadol Rapid Handipak, Panadol Soluble, Paralgin Paracetamol Tabsules, Pharmacist Childrens Paracetamol Colourfree 1-5 Years, Pharmacist Childrens Paracetamol Colourfree 5-12 Years, Pharmacy Health Colour Free Childrens Paracetamol, Gold Cross Paracetamol, Tylenol Cold Sore Throat, Alpha First Aid Supplies Paracetamol, Guardian Childrens Paracetamol 5-12 Years, Guardian Paracetamol, Guardian Paracetamol Tabsules, Acephen, Rex Paracetamol, Topcare Arthritis Pain Relief, Accidental First Aid Supplies Paracetamol, Panadol Childrens, Panadol Jr, Flu Strength Hot Lemon Powders, Paineze Paracetamol, Health Care Chemist Paracetamol Infant Drops Colour Free, Genebs, Herron Gold Paracetamol Tabsules, Tylenol Regular Strength, Herron Paracetamol, Tempra 2, Tempol, Herron Paracetamol Capseals, Tempra 3, Taminol, Herron Paracetamol Capseals Handy Pack, Herron Paracetamol Handy Pack, Apra, Claradol, Conacetol, Dolono, Doliprane Adultes, Coles Paracetamol, Genapap Extra Strength, Doliprane Sans Sucre, Dolitabs, Home Brand Paracetamol, Q-Pap Extra Strength, Dolko, ICN Paracetamol, Redutemp, Dolko Enfants, Dolotec, Vicks Formula 44 Custom Care Body Aches, James Dean Pharmacy Paracetamol, Efferalgan Pediatrique, Uniserts, Efferalganodis, Silapap Childrens, Expandox, Dolono Infant, Geluprane, Ed-APAP, Paracetamol EG, St. Joseph Aspirin-Free, Country Chemists Paracetamol, Paracetamol Ivax, Paracetamol Merck, Paracetamol Qualimed, Paracetamol Ranbaxy, Adprin B, BF-Paradac, Paracetamol RPG, Tempra Quicklets, Paracetamol Sandoz Conseil, Lloydspharmacy Paracetamol Six Plus, Paracetamol Winthrop, Triaminic Fever Reducer Pain Reliever, Lloydspharmacy Paracetamol Infant, Paracetamol Zydus, Triaminic Infant Drops, Atasol Forte, Paralyoc, Tylenol Cool Caplet Extra Strength, Acetaminophen-odan, Mapap Rapid Tabs, Jr. Tylenol, Mapap Extra Strength Rapid Burst, Elixsure Fever/Pain, Infadrops, Tactinal, Disprol Soluble Paracetamol, Disprol Paracetamol, Galpamol, Paldesic, Calpol Paediatric, Medinol Paediatric, Medinol Under 6, Infantaire Drops, Lemsip Pharmacy Non-Decongestant Formula, Cetafen, Calpol Six Plus, Masophen, Medinol Over 6, Nortemp Children's, Paracets, Anadin Paracetamol, Hedex, UN-Aspirin Extra Strength, Mandanol, Valorin, Actimol Children's, Dakota Paracetamol, Umphamol, Panamax 240, Parahexal, Mid West Products Numol Paracetamol, Parmol, Silapap Infants, Cuprofen for Children, Mapap Infant Drops, Mandanol Infant, Cetafen Extra, Mandanol 6+, Fennings Childrens Cooling, Duatrol SR, Aldi Hedanol Paracetamol, Under Ten Care Infant, Alphapharm Paracetamol, Amadol Paracetamol, No Frills Paracetamol, Tylenol Sore Throat Daytime, Nova Paracetamol, Mapap Meltaway, Numark Paracetamol, Amcal Childrens Paracetamol 1-5 Years, Nyal Paracetamol, Medi-Tabs, Amcal Childrens Paracetamol 5-12 Years, Orajel Maximum Strength Toothache, Amcal Paracetamol Pain Relief, Ordov Febrigesic Paracetamol, Topcare 8 Hour Pain Relief, Amcal Paracetamol Infant Drops 1 Month to 2 Years, Pain-Eze Paracetamol Infant Drops, Febridol Syrup for Children, Amcal Paracetamol Tabsules, Pharmacist Advice Colourfree Childrens Paracetamol Double Strength, Guardian Childrens Paracetamol, Pharmacist Formula Paracetamol, Pharmacist Formula Infants, Paraspen, RP Scherer Paracetamol, RP Scherer Paracetamol Liquid-Filled Capsules, Savings Paracetamol, Signature Range Paracetamol, Dymadon, Soul Pattinson Childrens Paracetamol Elixir, Soul Pattinson Colour Free Paracetamol 1-5 Years, Soul Pattinson Colour Free Paracetamol Drops, Soul Pattinson Colourfree Childrens Paracetamol, Panadol Gel Tabs, API Healthcare Coloufree Childrens Paracetamol, Soul Pattinson Paracetamol, API Healthcare Colourfree Childrens Paracetamol Double Strength, Soul Pattinson Paracetamol Clear Effervescent, Panadol Mini Caps, API Healthcare Paracetamol, Pharmacy Health Paracetamol, Terry White Chemists Colour Free Paracetamol 1-5 Years, Pharmacist Paracetamol, Terry White Chemists Colour Free Paracetamol Infant Drops)
  • acetaminophen / chlorpheniramine / pseudoephedrine (Sinarest, Kolephrin, Tylenol Allergy Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Singlet, Simplet, Tricom, Comtrex Allergy Sinus, Codimal, Allerest Sinus, Sinutab Ex-Strength, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Cold Medicine Plus, Actifed Cold & Sinus)
  • acetaminophen / diphenhydramine / pseudoephedrine (Actifed Sinus Day and Night, Benadryl Cold, Contac Day and Night Allergy, Sudafed Sinus Nighttime Plus Pain, Tylenol Allergy Complete NightTime, Benadryl Severe Allergy & Sinus Headache)
  • Actigall (ursodiol)
  • Aleve (naproxen)
  • Bactrim (sulfamethoxazole / trimethoprim)
  • Benadryl Allergy (diphenhydramine)
  • Dextromethorphan HBr Adult Formula (dextromethorphan)
  • Feosol Natural Release (carbonyl iron)
  • Flexeril (cyclobenzaprine)
  • Guaifen DM (dextromethorphan / guaifenesin)
  • Lantus (insulin glargine)
  • Lithobid (lithium)
  • Lyrica (pregabalin)
  • Maxalt (rizatriptan)
  • Mucinex (guaifenesin)
  • NovoLog PenFill (insulin aspart)
  • pseudoephedrine (Sudafed Congestion, SudoGest, Sudafed 12-Hour, Entex, Silfedrine, Chlor-Trimeton Nasal Decongestant, Sudafed Children's Nasal Decongestant, Efidac, Suphedrine, Cenafed, Contac Cold, Nexafed Nasal Decongestant, nasofed, Suphedrin, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Decofed Liquid, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Sudafed 24-Hour, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant)
  • Solodyn (minocycline)
  • Sonata (zaleplon)
  • Sudafed 12-Hour (pseudoephedrine)
  • Sudafed 24-Hour (pseudoephedrine)
  • Sudafed PE Congestion (phenylephrine)
  • Tylenol (acetaminophen)
  • Tylenol PM (acetaminophen / diphenhydramine)
  • Wellbutrin (bupropion)
  • Wellbutrin XL (bupropion)
  • Zoloft (sertraline)

Acetaminophen / pseudoephedrine alcohol/food interactions

There is 1 alcohol/food interaction with acetaminophen / pseudoephedrine

Acetaminophen / pseudoephedrine disease interactions

There are 9 disease interactions with acetaminophen / pseudoephedrine which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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