Acetaminophen/guaifenesin/phenylephrine Interactions
There are 339 drugs known to interact with acetaminophen/guaifenesin/phenylephrine, along with 7 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 35 are major, 283 are moderate, and 21 are minor.
- View all 339 medications that may interact with acetaminophen/guaifenesin/phenylephrine
- View acetaminophen/guaifenesin/phenylephrine alcohol/food interactions (3)
- View acetaminophen/guaifenesin/phenylephrine disease interactions (7)
Most frequently checked interactions
View interaction reports for acetaminophen / guaifenesin / phenylephrine and the medicines listed below.
- Allegra (fexofenadine)
- Allegra-D 24 Hour Allergy & Congestion (fexofenadine / pseudoephedrine)
- Beano (alpha-d-galactosidase)
- Benadryl (diphenhydramine)
- Benadryl Allergy (diphenhydramine)
- Dramamine (dimenhydrinate)
- Eliquis (apixaban)
- EpiPen (epinephrine)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Flovent HFA (fluticasone)
- Klonopin (clonazepam)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- Mucinex (guaifenesin)
- Mucinex D (guaifenesin / pseudoephedrine)
- Mucinex DM (dextromethorphan / guaifenesin)
- Norco (acetaminophen / hydrocodone)
- Pamprin Multi-Symptom Menstrual Relief (acetaminophen / pamabrom / pyrilamine)
- Phenergan (promethazine)
- ProAir HFA (albuterol)
- Pulmicort Flexhaler (budesonide)
- Restasis (cyclosporine ophthalmic)
- Singulair (montelukast)
- Toradol IM (ketorolac)
- Tylenol (acetaminophen)
- Vicks Dayquil Cold & Flu Relief (acetaminophen / dextromethorphan / phenylephrine)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Zyrtec (cetirizine)
Acetaminophen/guaifenesin/phenylephrine alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / guaifenesin / phenylephrine.
Acetaminophen/guaifenesin/phenylephrine disease interactions
There are 7 disease interactions with acetaminophen / guaifenesin / phenylephrine which include:
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Promethazine VC with Codeine
Promethazine VC with Codeine is used for cough and nasal congestion
Mucinex D
Mucinex D (guaifenesin and pseudoephedrine) is used to treat nasal and sinus congestion, and to ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Robitussin Nighttime Cough DM
Robitussin Nighttime Cough DM is used for cough, cough and nasal congestion
Vicks Nyquil Cough
Vicks Nyquil Cough is used for cough, cough and nasal congestion
Dextromethorphan/guaifenesin/phenylephrine
Dextromethorphan/guaifenesin/phenylephrine systemic is used for cough and nasal congestion
Brompheniramine/dextromethorphan/pseudoephedrine
Brompheniramine/dextromethorphan/pseudoephedrine systemic is used for cough and nasal congestion
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
