Skip to Content

Veklury Dosage

Generic name: REMDESIVIR 5mg in 1mL
Dosage form: injection

Medically reviewed by Drugs.com. Last updated on Oct 28, 2020.

Testing Before Initiating and During Treatment with VEKLURY

Determine eGFR in all patients before starting VEKLURY and monitor while receiving VEKLURY as clinically appropriate [see Dosage and Administration (2.3) and Use in Specific Populations (8.4, 8.6)].

Perform hepatic laboratory testing in all patients before starting VEKLURY and while receiving VEKLURY as clinically appropriate [see Warnings and Precautions (5.2) and Use in Specific Populations (8.7)].

Determine prothrombin time in all patients before starting VEKLURY and monitor while receiving VEKLURY as clinically appropriate [see Adverse Reactions (6.1)].

Recommended Dosage in Adults and Pediatric Patients 12 Years of Age and Older and Weighing at Least 40 kg

The recommended dosage for adults and pediatric patients 12 years of age and older and weighing at least 40 kg is a single loading dose of VEKLURY 200 mg on Day 1 via intravenous infusion followed by once-daily maintenance doses of VEKLURY 100 mg from Day 2 via intravenous infusion.

  • The recommended treatment duration for patients not requiring invasive mechanical ventilation and/or extracorporeal membrane oxygenation (ECMO) is 5 days. If a patient does not demonstrate clinical improvement, treatment may be extended for up to 5 additional days for a total treatment duration of up to 10 days.
  • The recommended total treatment duration for patients requiring invasive mechanical ventilation and/or ECMO is 10 days.
  • VEKLURY must be diluted prior to intravenous infusion. Refer to Dosage and Administration (2.4) for detailed preparation and administration instructions.

Renal Impairment

VEKLURY is not recommended in patients with eGFR less than 30 mL per minute [see Dosage and Administration (2.1) and Use in Specific Populations (8.6)].

Dose Preparation and Administration

  • VEKLURY must be prepared and administered under the supervision of a healthcare provider.
  • VEKLURY must be administered via intravenous infusion only. Do not administer by any other route.
  • VEKLURY is available in two dosage forms:
    • VEKLURY for injection (supplied as 100 mg lyophilized powder in vial) needs to be reconstituted with Sterile Water for Injection prior to diluting in a 100 mL or 250 mL 0.9% sodium chloride infusion bag.
    • VEKLURY injection (supplied as 100 mg/20 mL [5 mg/mL] solution in vial) must be diluted in a 250 mL 0.9% sodium chloride infusion bag.
  • Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Discard the vial if the lyophilized powder or solution is discolored or contains particulate matter. Prior to dilution in a 0.9% sodium chloride infusion bag, reconstituted VEKLURY for injection and VEKLURY injection solution should be a clear, colorless to yellow solution, free of visible particles.
  • Prepare diluted solution under aseptic conditions and on same day as administration.

VEKLURY for Injection (Supplied as 100 mg Lyophilized Powder in Vial)

Reconstitution Instructions

Remove the required number of single-dose vial(s) from storage. For each vial:

  • Aseptically reconstitute VEKLURY lyophilized powder by adding 19 mL of Sterile Water for Injection using a suitably sized syringe and needle per vial.
  • Only use Sterile Water for Injection to reconstitute VEKLURY lyophilized powder.
  • Discard the vial if a vacuum does not pull the Sterile Water for Injection into the vial.
  • Immediately shake the vial for 30 seconds.
  • Allow the contents of the vial to settle for 2 to 3 minutes. A clear solution should result.
  • If the contents of the vial are not completely dissolved, shake the vial again for 30 seconds and allow the contents to settle for 2 to 3 minutes. Repeat this procedure as necessary until the contents of the vial are completely dissolved. Discard the vial if the contents are not completely dissolved.
  • Following reconstitution, each vial contains 100 mg/20 mL (5 mg/mL) of remdesivir solution.
  • Use reconstituted product immediately to prepare the diluted drug product [see Dosage and Administration (2.5)].

Dilution Instructions

Care should be taken during admixture to prevent inadvertent microbial contamination. As there is no preservative or bacteriostatic agent present in this product, aseptic technique must be used in preparation of the final parenteral solution. It is always recommended to administer intravenous medication immediately after preparation when possible.

  • Reconstituted VEKLURY for injection, containing 100 mg/20 mL remdesivir solution, must be further diluted in either a 100 mL or 250 mL 0.9% sodium chloride infusion bag. Refer to Table 1 for instructions.
Table 1 Recommended Dilution Instructions—Reconstituted VEKLURY for Injection Lyophilized Powder
VEKLURY dose 0.9% sodium chloride infusion bag volume to be used Volume to be withdrawn and discarded from 0.9% sodium chloride infusion bag Required volume of reconstituted VEKLURY for injection
Loading dose
200 mg
(2 vials)
250 mL 40 mL 40 mL (2 × 20 mL)
100 mL 40 mL 40 mL (2 × 20 mL)
Maintenance dose
100 mg
(1 vial)
250 mL 20 mL 20 mL
100 mL 20 mL 20 mL
  • Withdraw and discard the required volume of 0.9% sodium chloride from the bag following instructions in Table 1, using an appropriately sized syringe and needle.
  • Withdraw the required volume of reconstituted VEKLURY for injection from the VEKLURY vial following instructions in Table 1, using an appropriately sized syringe. Discard any unused portion remaining in the reconstituted vial.
  • Transfer the required volume of reconstituted VEKLURY for injection to the selected infusion bag.
  • Gently invert the bag 20 times to mix the solution in the bag. Do not shake.
  • The prepared infusion solution is stable for 24 hours at room temperature (20°C to 25°C [68°F to 77°F]) or 48 hours at refrigerated temperature (2°C to 8°C [36°F to 46°F]).

Administration Instructions

Do not administer the prepared diluted solution simultaneously with any other medication. The compatibility of VEKLURY injection with intravenous solutions and medications other than 0.9% sodium chloride injection, USP is not known. Administer VEKLURY via intravenous infusion over 30 to 120 minutes.

Administer the diluted solution with the infusion rate described in Table 2.

Table 2 Recommended Rate of Infusion—Diluted VEKLURY for Injection Lyophilized Powder in Adults and Pediatric Patients 12 Years of Age and Older and Weighing at Least 40 kg
Infusion bag volume Infusion time Rate of infusion
250 mL 30 min 8.33 mL/min
60 min 4.17 mL/min
120 min 2.08 mL/min
100 mL 30 min 3.33 mL/min
60 min 1.67 mL/min
120 min 0.83 mL/min

VEKLURY Injection (Supplied as 100 mg/20 mL [5 mg/mL] Solution in Vial)

Dilution Instructions

Care should be taken during admixture to prevent inadvertent microbial contamination. As there is no preservative or bacteriostatic agent present in this product, aseptic technique must be used in preparation of the final parenteral solution. It is always recommended to administer intravenous medication immediately after preparation when possible.

  • Remove the required number of single-dose vial(s) from storage. Each vial contains 100 mg/20 mL of remdesivir. For each vial:
    • Equilibrate to room temperature (20°C to 25°C [68°F to 77°F]). Sealed vials can be stored up to 12 hours at room temperature prior to dilution.
    • Inspect the vial to ensure the container closure is free from defects and the solution is free of particulate matter.
    • VEKLURY injection must be diluted in an infusion bag containing 250 mL of 0.9% sodium chloride only. Refer to Table 3 for instructions.
Table 3 Recommended Dilution Instructions—VEKLURY Injection (Supplied as Solution in Vial)
VEKLURY dose 0.9% sodium chloride infusion bag volume to be used Volume to be withdrawn and discarded from 0.9% sodium chloride infusion bag Required volume of VEKLURY injection
Loading dose
200 mg
(2 vials)
250 mL 40 mL 40 mL (2 × 20 mL)
Maintenance dose
100 mg
(1 vial)
20 mL 20 mL
  • Withdraw and discard the required volume of 0.9% sodium chloride from the bag following instructions in Table 3, using an appropriately sized syringe and needle.
  • Withdraw the required volume of VEKLURY injection from the VEKLURY vial following instructions in Table 3, using an appropriately sized syringe.
    • Pull the syringe plunger rod back to fill the syringe with approximately 10 mL of air.
    • Inject the air into the VEKLURY injection vial above the level of the solution.
    • Invert the vial and withdraw the required volume of VEKLURY injection solution into the syringe. The last 5 mL of solution requires more force to withdraw.
  • Transfer the required volume of VEKLURY injection to the infusion bag.
  • Gently invert the bag 20 times to mix the solution in the bag. Do not shake.
  • The prepared infusion solution is stable for 24 hours at room temperature (20°C to 25°C [68°F to 77°F]) or 48 hours at refrigerated temperature (2°C to 8°C [36°F to 46°F]).

Administration Instructions

Do not administer the prepared diluted solution simultaneously with any other medication. The compatibility of VEKLURY injection with intravenous solutions and medications other than 0.9% sodium chloride injection, USP is not known. Administer VEKLURY via intravenous infusion over 30 to 120 minutes.

Administer the diluted solution with the infusion rate described in Table 4.

Table 4 Recommended Rate of Infusion—Diluted VEKLURY Injection Solution in Adults and Pediatric Patients 12 Years of Age and Older and Weighing at Least 40 kg
Infusion bag volume Infusion time Rate of infusion
250 mL 30 min 8.33 mL/min
60 min 4.17 mL/min
120 min 2.08 mL/min

Storage of Prepared Dosages

VEKLURY for Injection (Supplied as Lyophilized Powder in Vial)

After reconstitution, use vials immediately to prepare diluted solution. The diluted VEKLURY solution in the infusion bags can be stored up to 24 hours at room temperature (20°C to 25°C [68°F to 77°F]) prior to administration or 48 hours at refrigerated temperature (2°C to 8°C [36°F to 46°F]).

VEKLURY Injection (Supplied as Solution in Vial)

Store VEKLURY injection after dilution in the infusion bags up to 24 hours at room temperature (20°C to 25°C [68°F to 77°F]) or 48 hours at refrigerated temperature (2°C to 8°C [36°F to 46°F]).

IMPORTANT:

This product contains no preservative. Any unused portion of a single-dose VEKLURY vial should be discarded after a diluted solution is prepared.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.