Uloric Dosage
Generic name: febuxostat 40mg
Dosage form: tablet
Drug class: Antihyperuricemic agents
Medically reviewed by Drugs.com. Last updated on Apr 27, 2023.
Recommended Dosage
The recommended ULORIC dosage is 40 mg or 80 mg once daily.
The recommended starting dosage of ULORIC is 40 mg once daily. For patients who do not achieve a serum uric acid (sUA) less than 6 mg/dL after two weeks, the recommended ULORIC dosage is 80 mg once daily.
ULORIC can be taken without regard to food or antacid use.
Concurrent prophylactic treatment with a non-steroidal anti-inflammatory drug (NSAID) or colchicine is recommended.
Dosage Recommendations in Patients with Renal Impairment and Hepatic Impairment
The recommended dosage of ULORIC is limited to 40 mg once daily in patients with severe renal impairment. No dose modification is necessary when administering ULORIC in patients with mild or moderate renal impairment.
No dosage modification is necessary in patients with mild to moderate hepatic impairment.
Serum Uric Acid Level Monitoring
Testing for the target serum uric acid level of less than 6 mg/dL may be performed as early as two weeks after initiating ULORIC therapy.
Recommended Prophylaxis for Gout Flares
Gout flares may occur after initiation of ULORIC due to changing serum uric acid levels resulting in mobilization of urate from tissue deposits. Flare prophylaxis with a non-steroidal anti-inflammatory drug (NSAID) or colchicine is recommended upon initiation of ULORIC. Prophylactic therapy may be beneficial for up to six months.
If a gout flare occurs during ULORIC treatment, ULORIC need not be discontinued. The gout flare should be managed concurrently, as appropriate for the individual patient.
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