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Uloric Dosage

Generic name: febuxostat 40mg
Dosage form: tablet

Medically reviewed by Drugs.com. Last updated on Feb 28, 2019.

Recommended Dose

The recommended ULORIC dosage is 40 mg or 80 mg once daily.

The recommended starting dosage of ULORIC is 40 mg once daily. For patients who do not achieve a serum uric acid (sUA) less than 6 mg/dL after two weeks, the recommended ULORIC dosage is 80 mg once daily.

ULORIC can be taken without regard to food or antacid use [see Clinical Pharmacology (12.3)].

Dosage Recommendations in Patients with Renal Impairment and Hepatic Impairment

No dose adjustment is necessary when administering ULORIC in patients with mild or moderate renal impairment.

The recommended dosage of ULORIC is limited to 40 mg once daily in patients with severe renal impairment [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)].

No dose adjustment is necessary in patients with mild to moderate hepatic impairment [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)].

Uric Acid Level

Testing for the target serum uric acid level of less than 6 mg/dL may be performed as early as two weeks after initiating ULORIC therapy.

Recommended Prophylaxis for Gout Flares

Gout flares may occur after initiation of ULORIC due to changing serum uric acid levels resulting in mobilization of urate from tissue deposits. Flare prophylaxis with a non-steroidal anti-inflammatory drug (NSAID) or colchicine is recommended upon initiation of ULORIC. Prophylactic therapy may be beneficial for up to six months [see Clinical Studies (14.1)].

If a gout flare occurs during ULORIC treatment, ULORIC need not be discontinued. The gout flare should be managed concurrently, as appropriate for the individual patient [see Warnings and Precautions (5.2)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.