Skip to Content

Twinrix Dosage

Generic name: HEPATITIS A VIRUS STRAIN HM175 ANTIGEN (FORMALDEHYDE INACTIVATED) 720[iU] in 1mL, HEPATITIS B VIRUS SUBTYPE ADW2 HBSAG SURFACE PROTEIN ANTIGEN 20ug in 1mL
Dosage form: injection, suspension

Medically reviewed by Drugs.com. Last updated on Dec 18, 2018.

Preparation for Administration

The vaccine should be re-suspended before use. When re-suspended, the vaccine will have a uniform hazy white appearance.

Upon storage, a fine white deposit with a clear colorless layer above may be present. Re-suspend the vaccine following the steps below.

1. Hold the syringe upright in a closed hand.

2. Shake the syringe by tipping it upside down and back upright again.

3. Repeat this action vigorously for at least 15 seconds.

4. Inspect the vaccine again:

If the vaccine appears as a uniform hazy white suspension, it is ready to use – the appearance should not be clear.
If the vaccine still does not appear as a uniform hazy white suspension, tip upside down and back upright again for at least another 15 seconds then inspect again.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If either of these conditions exists, the vaccine should not be administered.

Attach a sterile needle to the prefilled syringe and administer intramuscularly.

Administration

TWINRIX should be administered by intramuscular injection only as a 1-mL dose. Administer in the deltoid region. Do not administer in the gluteal region; such injections may result in a suboptimal response.

Do not administer this product intravenously, intradermally, or subcutaneously.

Recommended Dose and Schedule

Standard dosing schedule consists of 3 doses (1-mL each), given intramuscularly at 0, 1, and 6 months. Alternatively, an accelerated schedule of 4 doses (1-mL each), given intramuscularly on Days 0, 7, and 21 to 30 followed by a booster dose at Month 12 may be used.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about Twinrix (hepatitis a adult vaccine / hepatitis b adult vaccine)

Consumer resources

Professional resources

Related treatment guides

Hide