Generic name: HEPATITIS A VIRUS STRAIN HM175 ANTIGEN (FORMALDEHYDE INACTIVATED) 720[iU] in 1mL, HEPATITIS B VIRUS SUBTYPE ADW2 HBSAG SURFACE PROTEIN ANTIGEN 20ug in 1mL
Dosage form: injection, suspension
Drug class: Vaccine combinations
Medically reviewed by Drugs.com. Last updated on Apr 28, 2023.
Preparation for Administration
The vaccine should be re-suspended before use. When re-suspended, the vaccine will have a uniform hazy white appearance.
Upon storage, a fine white deposit with a clear colorless layer above may be present. Re-suspend the vaccine following the steps below.
1. Hold the syringe upright in a closed hand.
2. Shake the syringe by tipping it upside down and back upright again.
3. Repeat this action vigorously for at least 15 seconds.
4. Inspect the vaccine again:
- If the vaccine appears as a uniform hazy white suspension, it is ready to use – the appearance should not be clear.
- If the vaccine still does not appear as a uniform hazy white suspension, tip upside down and back upright again for at least another 15 seconds then inspect again.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If either of these conditions exists, the vaccine should not be administered.
Attach a sterile needle to the prefilled syringe and administer intramuscularly.
TWINRIX should be administered by intramuscular injection only as a 1-mL dose. Administer in the deltoid region. Do not administer in the gluteal region; such injections may result in a suboptimal response.
Do not administer this product intravenously, intradermally, or subcutaneously.
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