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Twinrix Side Effects

Generic Name: hepatitis a adult vaccine / hepatitis b adult vaccine

Note: This document contains side effect information about hepatitis a adult vaccine / hepatitis b adult vaccine. Some of the dosage forms listed on this page may not apply to the brand name Twinrix.

For the Consumer

Applies to hepatitis a adult vaccine / hepatitis b adult vaccine: intramuscular suspension

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very bad dizziness or passing out.
  • A burning, numbness, or tingling feeling that is not normal.
  • Trouble controlling body movements.
  • Change in eyesight.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Pain where the shot was given.
  • Redness or swelling where the shot is given.
  • Headache.
  • Feeling tired or weak.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to hepatitis a adult vaccine / hepatitis b adult vaccine: intramuscular suspension

General

Hepatitis A-hepatitis B vaccine is generally well-tolerated. Most side effects were mild, self-limiting, and of short duration (less than 48 hours).[Ref]

Local

Local side effects have included soreness, redness, swelling, induration, pruritus, and ecchymosis at the injection site.[Ref]

Other

Other side effects have included headache, fatigue, fever, sweating, weakness, flushing, influenza-like symptoms, tingling, tinnitus, and earache.[Ref]

Cardiovascular

Cardiovascular side effects have included syncope, hypotension, tachycardia, and palpitations.[Ref]

Dermatologic

Dermatologic side effects have included rash, urticaria, petechiae, erythema, hyperhidrosis, angioedema, eczema, herpes zoster, erythema nodosum, and alopecia.[Ref]

Gastrointestinal

Gastrointestinal side effects have included diarrhea, nausea, vomiting, abdominal pain, anorexia, constipation, dysgeusia, and dyspepsia.[Ref]

Hematologic

Hematologic side effects have included lymphadenopathy and thrombocytopenia.[Ref]

Hepatic

Hepatic side effects have included jaundice, hepatitis, and abnormal liver function tests.[Ref]

Hypersensitivity

Hypersensitivity reactions have included anaphylaxis, anaphylactoid reactions, erythema multiforme, Stevens-Johnson syndrome, angioedema, arthritis, and serum-sickness-like syndrome (arthralgia, arthritis, fever, urticaria, erythema multiforme, ecchymoses, and erythema nodosum).[Ref]

Musculoskeletal

Musculoskeletal side effects have included arthralgia, myalgia, back pain, and creatine phosphokinase elevations.[Ref]

Nervous system

Nervous system side effects have included migraine, paresthesia, vertigo, somnolence, insomnia, irritability, agitation, dizziness, hypertonic episode, convulsions, paresis, encephalopathy, neuropathy, myelitis, Guillain-Barre syndrome, multiple sclerosis, Bell's palsy, and transverse myelitis.[Ref]

Ocular

Ocular side effects have included photophobia, optic neuritis, conjunctivitis, keratitis, and visual disturbances.[Ref]

Respiratory

Respiratory side effects have included upper respiratory tract infections, dyspnea, bronchospasm, and asthma-like symptoms.[Ref]

References

1. "Product Information. Twinrix (hepatitis A-hepatitis B vaccine)" SmithKline Beecham, Philadelphia, PA.

Some side effects of Twinrix may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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