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Triferic Dosage

Generic name: FERRIC PYROPHOSPHATE CITRATE 272mg in 272mg
Dosage form: powder for solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Recommended Dosage

Inspect Triferic solution in ampules for signs of precipitation prior to mixing with the bicarbonate concentrate. Triferic solution should appear slightly yellow-green in color.

Triferic solution or powder should only be added to the bicarbonate concentrate and should NOT be added to acid concentrate mixtures.

Add Triferic solution or powder to bicarbonate concentrate used for the generation of hemodialysate. The concentration of iron (III) in the final hemodialysate is 2 micromolar (110 mcg/L).

  • Add one 5 mL ampule of Triferic solution to 2.5 gallons (9.46 liters) of bicarbonate concentrate. Multiple 5 mL ampules can be added to the master bicarbonate mix at each center at a ratio of one 5 mL ampule for each 2.5 gallons (9.46 liters) of bicarbonate concentrate.
  • Add one 50 mL ampule of Triferic solution to 25 gallons (94.6 liters) of bicarbonate concentrate. Multiple 50 mL ampules can be added to the master bicarbonate mix at each center at a ratio of one 50 mL ampule for each 25 gallons (94.6 liters) of bicarbonate concentrate.
  • Add one packet of Triferic powder to 25 gallons (94.6 liters) of bicarbonate concentrate. Multiple packets can be added to the master bicarbonate mix at each center at a ratio of one packet for each 25 gallons (94.6 liters) of bicarbonate concentrate.

Product comparison table with dilution instructions for the 5 mL ampule of Triferic solution, the 50 mL ampule of Triferic Solution, and the packet of Triferic Powder are provided in the Table below.

Triferic Dosage Form Triferic Solution Triferic Powder
5 mL Ampule 50 mL Ampule Packet
Iron content per Ampule or Packet 27.2 mg 272 mg 272 mg
Number of Ampules or Packets to be added to each unit of bicarbonate concentrate 1 1 1
Per unit of bicarbonate concentrate (volume) 2.5 gallons
(9.46 Liters)
25 gallons
(94.6 Liters)
25 gallons
(94.6 Liters)
Final iron concentration in dialysate 110 mcg/L 110 mcg/L 110 mcg/L

Administer Triferic to patients at each dialysis procedure for as long as patients are receiving maintenance hemodialysis therapy for CKD.

Dosage of Triferic is expressed as mg of iron (III).

Hemodialysis solutions should be used within 24 hours of the preparation of the bicarbonate concentrate mixture.

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