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Purinethol Dosage

Generic name: MERCAPTOPURINE 50mg
Dosage form: tablet
Drug class: Antimetabolites

Medically reviewed by Drugs.com. Last updated on Dec 13, 2021.

Recommended Dosage

The recommended starting dosage of PURINETHOL is 1.5mg/kg to 2.5 mg/kg orally once daily as part of combination chemotherapy maintenance regimen. A recommended dosage for patients less than 17 kg is not achievable, because the only available strength is 50 mg. Take PURINETHOL either consistently with or without food.

After initiating PURINETHOL, monitor complete blood count (CBC) and adjust the dose to maintain absolute neutrophil count (ANC) at a desirable level and for excessive myelosuppression. Evaluate the bone marrow in patients with prolonged myelosuppression or repeated episodes of myelosuppression to assess leukemia status and marrow cellularity.

Evaluate thiopurine S-methyltransferase (TPMT) and nucleotide diphosphatase (NUDT15) status in patients with severe myelosuppression or repeated episodes or myelosuppression [see Dosage and Administration (2.2)] .

Do not administer to patients who are unable to swallow tablets.

If a patient misses a dose, instruct the patient to continue with the next scheduled dose.

PURINETHOL is a cytotoxic drug. Follow special handling and disposal procedures.

Dosage Modifications in Patients with TPMT and NUDT15 Deficiency

Consider testing for TPMT and NUDT15 deficiency in patients who experience severe myelosuppression or repeated episodes of myelosuppression [see Warnings and Precautions (5.1), Clinical Pharmacology (12.5)] .

Homozygous Deficiency in either TPMT or NUDT15

Patients with homozygous deficiency of either enzyme typically require 10% or less of the recommended dosage. Reduce the recommended starting dosage of PURINETHOL in patients who are known to have homozygous TPMT or NUDT15 deficiency.

Heterozygous Deficiency in TPMT and/or NUDT15

Reduce the PURINETHOL dose based on tolerability. Most patients with heterozygous TPMT or NUDT15 deficiency tolerate the recommended dosage, but some require a dose reduction based on adverse reactions. Patients who are heterozygous for both TPMT and NUDT15 may require more substantial dose reductions.

Dosage Modifications in Renal and Hepatic Impairment

Renal Impairment

Use the lowest recommended starting dosage for PURINETHOL in patients with renal impairment (CLcr less than 50 mL/min). Adjust the dosage to maintain absolute neutrophil count (ANC) at a desirable level and for adverse reactions [see Uses in Specific Populations (8.6)] .

Hepatic Impairment

Use the lowest recommended starting dosage for PURINETHOL in patients with hepatic impairment. Adjust the dosage to maintain absolute neutrophil count (ANC) at a desirable level and for adverse reactions [see Uses in Specific Populations (8.7)] .

Dosage Modification with Concomitant Use of Allopurinol

Reduce the dose of PURINETHOL to one-third to one-quarter of the current dosage when coadministered with allopurinol [see Drug Interactions (7.1)] .

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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