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Phospholine Iodide Dosage

Generic name: echothiophate iodide 6.25mg in 5mL;
Dosage form: ophthalmic solution
Drug class: Ophthalmic glaucoma agents

  1. Use aseptic technique.
  2. Tear off aluminum seals, and remove and discard rubber plugs from both drug and diluent containers.
  3. Pour diluent into drug container.
  4. Remove dropper assembly from its sterile wrapping. Holding dropper assembly by the screw cap and, WITHOUT COMPRESSING RUBBER BULB, insert into drug container and screw down tightly.
  5. Shake for several seconds to ensure mixing.
  6. Do not cover nor obliterate instructions to patient regarding storage of eyedrops.

Elevated IOP

Echothiophate iodide for ophthalmic solution one drop instilled twice a day, just before retiring and in the morning. A change in therapy is indicated if, at any time, the tension fails to remain at an acceptable level on this regimen.

Two doses a day are preferred to one in order to maintain as smooth a diurnal tension curve as possible, although a single dose per day or every other day has been used with satisfactory results. The daily dose or one of the two daily doses should always be instilled just before retiring to avoid inconvenience due to the miosis.

Technique – Technique in the administration of echothiophate iodide for ophthalmic solution may include finger pressure at the inner canthus exerted for a minute or two following instillation of the eyedrops, to potentially minimize drainage into the nose and throat. Excess solution around the eye should be removed with tissue and any medication on the hands should be rinsed off.

Accommodative Esotropia (Pediatric Use)

In Diagnosis – One drop may be instilled once a day in both eyes on retiring, for a period of two or three weeks. If the esotropia is accommodative, a favorable response will usually be noted which may begin within a few hours.

In Treatment – Echothiophate iodide for ophthalmic solution is prescribed at the lowest frequency which gives satisfactory results. After the initial period of treatment for diagnostic purposes, the schedule may be reduced to one drop every other day. The maximum usually recommended dosage is one drop once a day, although more intensive therapy has been used for short periods.


Duration of Treatment — In therapy, there is no definite limit so long as the drug is well tolerated. However, if the eyedrops, with or without eyeglasses, are gradually withdrawn after about a year or two and deviation recurs, surgery should be considered. As with other miotics, tolerance may occasionally develop after prolonged use. In such cases, a rest period may restore the original activity of the drug.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.