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Peginterferon Beta-1A Dosage

Medically reviewed by Last updated on Aug 3, 2021.

Applies to the following strengths: 125 mcg/0.5 mL

Usual Adult Dose for Multiple Sclerosis

Day 1: 63 mcg subcutaneously
Day 15: 94 mcg subcutaneously
Day 29 and every 14 days thereafter: 125 mcg subcutaneously


  • Patient should be advised to rotate injection sites (abdomen, back of the upper arm, and thigh).
  • Prefilled pens and syringes are for single dose only and should be discarded after use.
  • Prophylactic and concurrent use of analgesics and/or antipyretics and dose titration may prevent or reduce influenza-like symptoms sometimes experienced.

Use: For the treatment of patients with relapsing forms of multiple sclerosis (MS)

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Data not available



  • Hypersensitivity to the active component or any of the ingredients

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Each hemodialysis reduces the concentration of this drug by approximately 24%.

Other Comments

Administration advice:

  • If a dose is missed, it should be administered as soon as possible.
  • If 7 days or more to the next planned dose: Patients should administer their missed dose immediately. Therapy can then continue with the next scheduled dose as planned.
  • If less than 7 days to the next planned dose: Patients should begin a new 2-week dosing schedule starting from when they administer their missed dose. A patient should not administer 2 doses within 7 days of each other.
Patients should be advised to rotate sites for injections. The usual sites are abdomen, back of the upper arm, and thigh.

Storage requirements:
  • Store in a refrigerator between 2C to 8C (36F to 46F).
  • Do not freeze.
  • Allow drug to warm to room temperature (about 30 minutes) prior to use.
  • Store in the closed original carton to protect from light.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.