Magnesium Sulfate Dosage
Applies to the following strength(s): 50% ; 10 mg/mL-D5% ; 20 mg/mL-D5% ; 40 mg/mL-D5% ; 80 mg/mL-D5% ; 125 mg/mL ; 10 g/1000 mL ; 40 mg/mL ; 80 mg/mL ; 100 mg/mL ; 20 g/500mL-sterile water ; 40 g/1000 mL-sterile water ; 4 g/100 mL-sterile water ; 2 g/50 mL-sterile water ; 1 g/50 mL-D5% ; 2 g/50 mL-D5% ; 6 g/50 mL-D5% ; 4 g/100 mL-NaCl 0.9% ; 1 g/50 mL-NaCl 0.9% ; 1 g/100 mL-NaCl 0.9% ; 2 g/50 mL-NaCl 0.9% ; 6 g/50 mL-NaCl 0.9% ; 3 g added to NaCl 0.9% 50 mL ; 6 g added to NaCl 0.9% 100 mL ; 2 g added to D5% 50 mL ; 4 g added to D5% 100 mL ; 50 g added to LR 500 mL ; 20 g added to LR 500 mL ; 10 g added to D5% 250 mL ; 3 g added to D5% 100 mL ; 40 mg/mL-LR ; 80 mg/mL-LR ; 120 mg/mL-D5% ; 83 mg/mL-D5% ; 83 mg/mL-LR ; 1000 mg/ 50 mL-NaCl 0.9% ; 2 g/100 mL-NaCl 0.9% ; 2 g/100 mL-D5% ; 6 g/100 mL-D5%
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypomagnesemia
1 g IM every 6 hours for 4 doses (mild hypomagnesemia) or
as much as 2 mEq/kg (0.5 mL of a 50% solution) within 4 hours if necessary (more severe hypomagnesemia) or
5 g in 1 L IV fluid over 3 hours.
Administration should be discontinued as soon as the desired clinical effect is achieved and the serum level is normal.
Usual Adult Dose for Ventricular Arrhythmia
Initial dose: 1 to 3 g IV bolus over 2 to 15 minutes.
Most studies have continued infusions for 24 to 48 hours.
A 1 to 3 g bolus may be repeated in 15 minutes.
Thereafter, 1 to 2 g may be administered by continuous IV infusion.
Usual Adult Dose for Seizure Prophylaxis
Seizure Prevention in Preeclampsia/Eclampsia:
Initial: IM: 4 to 5 g of a 50% solution every 4 hours as necessary.
IV: 4 g of a 10% to 20% solution, not exceeding 1.5 mL/min of a 10% solution.
Maintenance: IV Infusion: 1 to 2 g/hour. Maximum dose should not exceed 30 to 40 g/day.
Duration: Continuous administration beyond 5 to 7 days can cause fetal harm.
Renal Dose Adjustments
Patients in severe renal failure should not receive magnesium due to the potential for toxicity from accumulation.
Liver Dose Adjustments
Data not available
Use with caution or not at all in patients with a creatinine clearance of less than 25 mL/min. Patients with a creatinine clearance of less than 25 mL/min who do receive magnesium should have magnesium levels monitored.
Data not available
When possible, oral magnesium should be used for mild to moderate chronic hypomagnesemia (renal wasting).
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