Lebrikizumab Dosage

Medically reviewed by Drugs.com. Last updated on Dec 19, 2024.

Usual Adult Dose for Atopic Dermatitis

• Initial dose: 500 mg subcutaneously at week 0 and week two, followed by 250 mg subcutaneously every two weeks until week sixteen
• Maintenance dose: 250 mg subcutaneously every four weeks

Comments:

• If a dose is missed, administer the dose as soon as possible. Thereafter, resume dosing at the regular scheduled time.
• See manufacturer product information for complete administration instructions.

Use: For the treatment of adults and pediatric patients 12 years of age and older who weigh at least 40 kg with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable

Usual Pediatric Dose for Atopic Dermatitis

12 years and older who weigh at least 40 kg:

• Initial dose: 500 mg subcutaneously at week 0 and week two, followed by 250 mg subcutaneously every two weeks until week sixteen
• Maintenance dose: 250 mg subcutaneously every four weeks

Comments:

• If a dose is missed, administer the dose as soon as possible. Thereafter, resume dosing at the regular scheduled time.
• See manufacturer product information for complete administration instructions.

Use: For the treatment of adults and pediatric patients 12 years of age and older who weigh at least 40 kg with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

CONTRAINDICATIONS:
Prior serious hypersensitivity to this drug or any excipients.

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice

• This medication should be given by an adult.
• Provide patient or caregiver with training on the proper way to prepare and administer this medication.
• Administer the injection in alternating sites, which include the abdomen, thigh, and back of upper arm.

Storage requirements:

• Refrigerate at 2C to 8C (36F to 46F), protect from light.
• May be kept at room temperature up to 30C (86F) for up to 7 days in the original carton.
• Do not freeze.

Reconstitution/preparation techniques:

• Do not use if it contains visible particles, is discolored or cloudy.
• Remove prefilled pen or syringe from the refrigerator and let stand at room temperature without removing the needle cap for 45 minutes. Do not use a heat source such as hot water, microwave, or direct sunlight to warm the solution.

Patient advice:

• Read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
• Store in original carton to protect from light.
• Do not shake.
• Discard with needle shield after use in a puncture-resistant container.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer