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Firdapse Dosage

Generic name: amifampridine phosphate 10mg
Dosage form: tablet

Medically reviewed by Drugs.com. Last updated on Nov 25, 2019.

Dosage Information

  • The recommended starting dosage of FIRDAPSE is 15 mg to 30 mg daily, taken orally in divided doses (3 to 4 times daily).
  • The dosage can be increased by 5 mg daily every 3 or 4 days.
  • The maximum recommended total daily dosage is 80 mg.
  • The maximum single dose is 20 mg.
  • If a dose is missed, patients should not take double or extra doses.

Patients with Renal Impairment

The recommended starting dosage of FIRDAPSE in patients with renal impairment (creatinine clearance 15 to 90 mL/min) is 15 mg daily, taken orally in 3 divided doses. No dosage recommendation for FIRDAPSE can be made for patients with end-stage renal disease [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3, 12.5)].

Patients with Hepatic Impairment

The recommended starting dosage of FIRDAPSE in patients with any degree of hepatic impairment is 15 mg daily, taken orally in 3 divided doses [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3, 12.5)].

Known N-acetyltransferase 2 (NAT2) Poor Metabolizers

The recommended starting dosage of FIRDAPSE in known N-acetyltransferase 2 (NAT2) poor metabolizers is 15 mg daily, taken orally in 3 divided doses [see Use in Specific Populations (8.8) and Clinical Pharmacology (12.3, 12.5)].

Administration Instructions

FIRDAPSE can be taken without regard to food.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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