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Ferumoxytol Dosage

Applies to the following strength(s): 30 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Iron Deficiency Anemia

Initial dose: 510 mg, IV, over at least 15 minutes
Second dose: 510 mg, IV, over at least 15 minutes, 3 to 8 days after the initial dose

Comments:
-The patient should be reclined or semi-reclined during administration.
-Evaluate hematologic response at least one month after the second infusion.
-May be readministered for persistent or recurrent iron deficiency anemia.

Use: Iron deficiency anemia in adult patients with chronic kidney disease.

Renal Dose Adjustments

See Usual Adult Dose

Liver Dose Adjustments

Data not available

Precautions

BOXED WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS
-Fatal and serious hypersensitivity reactions including anaphylaxis have occurred.
-Initial symptoms may include hypotension, syncope, unresponsiveness, and cardiac/cardiorespiratory arrest.
-Hypersensitivity reactions have occurred in patients who previously tolerated the product.
Recommendations:
-Only administer when personnel and therapies for anaphylaxis/hypersensitivity are immediately available.
-Observe for symptoms of hypersensitivity during and for 30 minutes after administration, including monitoring of blood pressure and pulse.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: No adjustment recommended.
Peritoneal dialysis: Data not available

Comments:
-Administer once blood pressure is stable and the patient has completed at least 1 hour of hemodialysis.
-Monitor for hypotension following each infusion.

Other Comments

Administration advice:
-The patient should be reclined or semi-reclined during administration.
-Allow at least 30 minutes before administering other medications that can cause hypersensitivity and/or hypotension (e.g. chemotherapy, monoclonal antibodies).

Reconstitution/preparation techniques:
-Dilute in 50 to 200 mL of 0.9% sodium chloride or 5% dextrose solution.
-Immediate administration of diluted solution is recommended; may be stored up to 4 hours at controlled room temperature.

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