Skip to main content

Erlotinib Dosage

Medically reviewed by Last updated on Aug 14, 2023.

Applies to the following strengths: 25 mg; 100 mg; 150 mg

Usual Adult Dose for Non-Small Cell Lung Cancer

150 mg orally once a day on an empty stomach (at least 1 hour before or 2 hours after food)

Use: For patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations receiving first-line, maintenance, or second or greater line treatment after progression following at least one prior chemotherapy regimen

Usual Adult Dose for Pancreatic Cancer

100 mg orally once a day on an empty stomach (at least 1 hour before or 2 hours after food)

Use: For first-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer, in combination with gemcitabine

Renal Dose Adjustments

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.

Liver Dose Adjustments

Therapy should be interrupted or discontinued if:

Dose Adjustments

Discontinue therapy for:

Interrupt therapy:

If severe reactions occur with concomitant use of strong CYP450 3A4 inhibitors (e.g., atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin, voriconazole), or grapefruit or grapefruit juice, or when using concomitantly with an inhibitor of both CYP450 3A4 and CYP450 1A2 (e.g., ciprofloxacin): Reduce dose by 50 mg decrements and avoid concomitant use if possible

Concomitant use with CYP450 3A4 inducers (e.g., rifampin, rifabutin, rifapentine, phenytoin, carbamazepine, phenobarbital, St. John's Wort: Increase dose by 50 mg increments every 2 weeks to a maximum dose of 450 mg as tolerated; avoid concomitant use if possible

Concurrent cigarette smoking: Increase the dose by 50 mg every 2 weeks to a maximum dose of 300 mg. Upon cessation of smoking, immediately reduce dose to the recommended dose (150 mg or 100 mg daily)

Proton pump inhibitors: Avoid concomitant use if possible; separation of doses may not eliminate the interaction since proton pump inhibitors affect the pH of the upper GI tract for an extended period

H2-receptor antagonists: Erlotinib must be taken 10 hours after the H2-receptor antagonist and at least 2 hours before the next dose of the H2-receptor antagonist

Antacids: The antacid dose and the dose of erlotinib should be separated by several hours, if an antacid is necessary; the effect of antacids on erlotinib pharmacokinetics has not been evaluated


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:


Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.