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Elacestrant Dosage

Medically reviewed by Drugs.com. Last updated on Oct 17, 2023.

Applies to the following strengths: 86 mg; 345 mg

Usual Adult Dose for Breast Cancer

345 mg orally once a day with food
Duration of therapy: Until disease progression or unacceptable toxicity

Use: For the treatment of postmenopausal women or adult men with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Mild liver dysfunction (Child-Pugh A): No adjustment recommended
Moderate liver dysfunction (Child-Pugh B): 258 mg orally once a day with food
Severe liver dysfunction (Child-Pugh C): Avoid use

Dose Adjustments

Avoid concomitant use with strong or moderate CYP450 3A4 inducers and inhibitors.

DOSE MODIFICATIONS FOR ADVERSE REACTIONS:


DOSE REDUCTION LEVELS FOR ADVERSE REACTIONS:

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.