Dacomitinib Dosage
Medically reviewed by Drugs.com. Last updated on Jun 3, 2024.
Applies to the following strengths: 15 mg; 30 mg; 45 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Non-Small Cell Lung Cancer
45 mg orally once a day until disease progression or unacceptable toxicity
Use: For the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 L858R substitution mutations as detected by an FDA-approved test
Renal Dose Adjustments
Mild (60 to less than 90 mL/min) and moderate (30 less than 60 mL/min) renal impairment: No adjustment recommended.
Severe renal impairment (CrCl less than 30 mL/min): Data not available
Liver Dose Adjustments
Mild (total bilirubin less than or equal to the upper limit of normal [ULN] with AST greater than ULN or total bilirubin greater than 1 to 1.5 x ULN with any AST) or moderate (total bilirubin greater than 1.5 to 3 x ULN and any AST) hepatic impairment: No adjustment recommended.
Severe (total bilirubin greater than 3 to 10 x ULN and any AST) hepatic impairment: Data not available
Dose Adjustments
DOSE REDUCTIONS FOR ADVERSE REACTIONS:
- First dose reduction: 30 mg orally once a day
- Second dose reduction: 15 mg orally once a day
DOSE MODIFICATIONS FOR ADVERSE REACTIONS:
INTERSTITIAL LUNG DISEASE (ILD):
- Any Grade: Permanently discontinue therapy.
- Grade 2: Withhold therapy until recovery to Grade 1 or less; resume at same dose level. For recurrent Grade 2 diarrhea, withhold until recovery to Grade 1 or less; resume at reduced dose.
- Grade 3 or 4: Withhold therapy until recovery to Grade 1 or less; resume at reduced dose.
- Grade 2: Withhold therapy until recovery to Grade 1 or less; resume at same dose level. For recurrent persistent Grade 2 reactions, withhold until recovery to Grade 1 or less; resume at reduced dose.
- Grade 3 or 4: Withhold therapy until recovery to Grade 1 or less; resume at reduced dose.
- Grade 3 or 4: Withhold therapy until recovery to Grade 2 or less; resume at reduced dose.
DOSE MODIFICATIONS FOR ACID-REDUCING AGENTS:
- Avoid concomitant use of proton pump inhibitors (PPIs) with this drug.
- Use locally acting antacids or if using a histamine 2 (H2)-receptor antagonist, administer this drug at least 6 hours before or 10 hours after.
Precautions
CONTRAINDICATIONS:
- None
This drug is not recommended for use in children.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- This drug may be taken with or without food.
- Take this drug at the same time each day.
- If the patient vomits or misses a dose, do not take an additional dose or make up a missed dose but continue with the next scheduled dose.
Storage requirements:
- Store at 20C to 25C (68F to 77F); excursions permitted between 15C to 30C (59F to 86F).
General:
- Concomitant use of proton pump inhibitors (PPIs) with this drug should be avoided.
- Treatment with this drug should be initiated and supervised by a physician experienced in the use of anticancer medicinal products.
Frequently asked questions
More about dacomitinib
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.