Cyklokapron Dosage
Generic name: TRANEXAMIC ACID 100mg in 1mL
Dosage form: injection, solution
Drug class: Miscellaneous coagulation modifiers
Medically reviewed by Drugs.com. Last updated on Sep 3, 2025.
Recommended Dosage
The recommended dose of CYKLOKAPRON is 10 mg/kg actual body weight administered as a single intravenous dose immediately before tooth extractions. Following tooth extraction, CYKLOKAPRON may be administered at a dose of 10 mg/kg actual body weight intravenously 3 to 4 times daily for 2 to 8 days.
Recommended Dosage for Patients With Varying Degrees of Renal Impairment
For patients with moderate to severe impaired renal function, the following dosages are recommended:
|
|
|
Serum Creatinine (mg/dL) |
CYKLOKAPRON Dosage |
|
1.36 mg/dL to 2.83 mg/dL |
10 mg/kg intravenously twice daily |
|
2.83 mg/dL to 5.66 mg/dL |
10 mg/kg intravenously daily |
|
>5.66 mg/dL |
10 mg/kg intravenously every 48 hours |
Preparation and Administration
CYKLOKAPRON is for intravenous administration only.
CYKLOKAPRON can be administered undiluted or as a diluted solution.
- •
- Use aseptic technique to prepare CYKLOKAPRON.
- •
- Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. CYKLOKAPRON is a clear and colorless solution. Discard the vial if particulate matter is observed.
- •
- Calculate the dose (mg) based on the patient’s actual body weight and the total volume (mL) of CYKLOKAPRON solution required.
If diluting CYKLOKAPRON, follow the instructions below:
- •
- From the diluent infusion bag, withdraw a volume equal to the volume of the CYKLOKAPRON solution required for the patient’s dose.
- •
- Withdraw the required volume of CYKLOKAPRON solution from the vial and dilute with a compatible diluent (see below) to make a final concentration of 10 mg/mL or 20 mg/mL. Discard any unused portion left in the vial.
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- For intravenous infusion, CYKLOKAPRON Injection may be mixed with most solutions for infusion such as electrolyte solutions, carbohydrate solutions, amino acid solutions, and Dextran solutions.
- o
- Heparin may be added to CYKLOKAPRON Injection.
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- CYKLOKAPRON Injection should NOT be mixed with blood.
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- The drug is a synthetic amino acid and should NOT be mixed with solutions containing penicillin.
- •
- Gently invert the infusion bag to mix the diluted solution. DO NOT SHAKE.
- •
- If not used immediately, store the diluted CYKLOKAPRON infusion solution at room temperature 20ºC to 25°C (68ºF to 77°F) for up to 4 hours.
Administration
Infuse undiluted solution no more than 1 mL/minute to avoid hypotension.
Administer the undiluted and diluted solutions intravenously according to Table 2.
|
Undiluted solution |
Diluted solution |
||
|
Final concentration |
100 mg/mL |
10 mg/mL |
20 mg/mL |
|
Administration rate |
0.5 mL/minute |
5 mL/minute |
2.5 mL/minute |
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
