Corlopam Dosage
Generic name: FENOLDOPAM MESYLATE 10mg in 1mL
Dosage form: injection, solution
Drug class: Agents for hypertensive emergencies
Medically reviewed by Drugs.com. Last updated on Jul 31, 2024.
Recommended Dosage
Adult Patients
Initiate dosing at 0.01 to 0.3 mcg/kg/min as a continuous intravenous infusion. Dosing may be increased in increments of 0.05 to 0.1 mcg/kg/minute every 15 minutes or longer, until target blood pressure is reached; the maximal infusion rate reported in clinical studies was 1.6 mcg/kg/minute. Doses lower than 0.1 mcg/kg/min and slow up-titration have been associated with less reflex tachycardia. Maintenance infusions may be continued for up to 48 hours.
Oral antihypertensive agents can be added during fenoldopam infusion or after discontinuation.
Pediatric Patients
Initiate dosing at 0.2 mcg/kg/minute and titrate dose by 0.3 to 0.5 mcg/kg/min every 20-30 minutes to a maximum dose of 0.8 mcg/kg/minute. Higher doses generally produced no further decreases in Mean Arterial Pressure (MAP) but did worsen tachycardia.
Preparation and Administration
Dilute contents of vials with 0.9% Sodium Chloride Injection or 5% Dextrose in Water before infusion. Each vial is for single use only. Discard diluted solution if not being administered to a patient after 4 hours at room temperature or 24 hours at refrigerated temperature. Inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If particulate matter or cloudiness is observed, discard the drug.
mL of Concentrate (mg of drug) |
Added to |
Final Concentration |
4 mL (40 mg) |
1000 mL |
40 mcg/mL |
2 mL (20 mg) |
500 mL |
40 mcg/mL |
1 mL (10 mg) |
250 mL |
40 mcg/mL |
mL of Concentrate (mg of drug) |
Added to |
Final Concentration |
3 mL (30 mg) |
500 mL |
60 mcg/mL |
1.5 mL (15 mg) |
250 mL |
60 mcg/mL |
0.6 mL (6 mg) |
100 mL |
60 mcg/mL |
Rates of infusion in mL/hour for fenoldopam may be calculated using the following formula:
Infusion Rate (mL/h) = [Dose (mcg/kg/min) x Weight (kg) x 60 min/h]
Concentration (mcg/mL)
Example calculations for infusion rates are as follows:
Example 1: for a 60 kg patient at an initial dose of 0.01 mcg/kg/min using a 40 mcg/mL concentration, the infusion rate would be as follows:
Infusion Rate (mL/h) = [0.01 (mcg/kg/min) x 60 (kg) x 60 (min/h)] = 0.9 (mL/h)
40 (mcg/mL)
Example 2: for a 10 kg patient at a dose of 0.2 mcg/kg/min using a 60 mcg/mL concentration, the infusion rate would be as follows:
Infusion Rate (mL/h) = [0.2 (mcg/kg/min) x 10 (kg) x 60 (min/h)] = 2.0 (mL/h)
60 (mcg/mL)
More about Corlopam (fenoldopam)
- Check interactions
- Compare alternatives
- Side effects
- During pregnancy
- Drug class: agents for hypertensive emergencies
- Breastfeeding
- En español
Patient resources
Professional resources
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.