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Cobicistat / Darunavir / Emtricitabine / Tenofovir Alafenamide Dosage

Medically reviewed by Drugs.com. Last updated on Sep 10, 2024.

Applies to the following strengths: 150 mg-800 mg-200 mg-10 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for HIV Infection

1 tablet orally once a day

Comments:


Use: As a complete regimen for the treatment of HIV-1 infection in patients with no prior antiretroviral treatment history or in patients virologically-suppressed (HIV-1 RNA less than 50 copies/mL) on a stable antiretroviral regimen for at least 6 months who have no known substitutions associated with resistance to darunavir or tenofovir

Usual Pediatric Dose for HIV Infection

At least 40 kg: 1 tablet orally once a day

Comments:


Use: As a complete regimen for the treatment of HIV-1 infection in patients with no prior antiretroviral treatment history or in patients virologically-suppressed (HIV-1 RNA less than 50 copies/mL) on a stable antiretroviral regimen for at least 6 months who have no known substitutions associated with resistance to darunavir or tenofovir

Renal Dose Adjustments

CrCl at least 30 mL/min: No adjustment recommended.
CrCl less than 30 mL/min: Not recommended.

Liver Dose Adjustments

Mild or moderate liver dysfunction (Child-Pugh A or B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh C): Not recommended.

Precautions

US BOXED WARNING:


CONTRAINDICATIONS:

Safety and efficacy have not been established in pediatric patients weighing less than 40 kg.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.